Ginsenoside Rg1

製品コードS3923 バッチS392302

印刷

化学情報

Synonyms

Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₄₂H₇₂O₁₄

分子量

801.01

CAS No.

22427-39-0

Solubility (25°C)*

体外

体内（毎回新しく調製した物を用意してください）

Clear solution

5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O

この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。

4.000mg/ml (4.99mM)

Taking the 1 mL working solution as an example, add 50 μL of 80 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

生物活性

製品説明	Ginsenoside Rg1 (Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1), one of the major active components of ginseng, is identified as a protopanaxatriol-type and has pharmacological actions such as neuroprotective and anti-tumor effects on various cancer types. Ginsenoside Rg1 reduces cerebral Aβ levels and NF-κB nuclear translocation.
in vitro	Ginsenoside Rg1 (Rg1) activates promyogenic kinases, p38MAPK (mitogen-activated protein kinase) and Akt signaling, that in turn promotes the heterodimerization with MyoD and E proteins, resulting in enhancing myogenic differentiation. Through the activation of Akt/mammalian target of rapamycin pathway, this compound induces myotube growth and prevents dexamethasone-induced myotube atrophy. Furthermore, it increases MyoD-dependent myogenic conversion of fibroblast. This chemical enhances glucose uptake in insulin-resistant myoblasts^[1]. It possesses the capacity for anti-aging activity in HSCs both in vitro and vivo^[2]. This compound promotes endothelial progenitor cells (EPCs) adhesion, proliferation, migration and in vitro vasculogenesis in a dose- and time-dependent manner^[3]. It could prevent cellular apoptosis via initiating an autophagic survival response, during which time this chemical could promote the expression of Beclin1 and Bcl-2 and weaken the interaction between Beclin1 and Bcl-2^[4].
in vivo	Rg1 can protect BMSCs against senescence and affect cell cycle phase distribution of bone marrow stromal cells (BMSCs) in aged rats. It affects inflammatory cytokine and stem cell factor (SCF) levels of BMSCs. This compound affects inflammatory cytokine and SCF levels of BMSCs. It improves the anti-aging ability of hematopoietic microenvironment through enhancing the anti-oxidant and anti-inflammatory capacities of BMSCs^[2]. This chemical has neuroprotective properties in neurodegenerative diseases such as AD. It could ameliorate cognitive impairment in the mouse model of AD, improve the learning and memory abilities, decrease the levels of cerebral Aβ, maintain hippocampal neuron activity, and prevent cellular apoptosis induced by Aβ accumulation. On the other hand, this compound also could protect against brain aging by enhancing the scavenging of free radicals in the brain^[5].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Myoblast C2C12 cells
	濃度	1, 5, 10, 50 nM
	反応時間	2 days
	実験の流れ	For the induction of myogenic differentiation, C2C12 cells are exchanged from growth medium (GM) containing 15% FBS to differentiation medium (DM) containing 2% HS. The efficiency of the myoblast differentiation is quantified. To induce hypertrophic myoblast differentiation, C2C12 cells are differentiated for 2 d and then treated with this compound for additional 2 days in DM. For the DEX-induced atrophy study, C2C12 cells are triggered to differentiate for 24 hrs and treated with 25 μM DEX and 10 nM of this chemical, followed by incubation in DM for 2 days.
動物実験	動物モデル	male Sprague-Dawley rats
	投薬量	20 mg/kg·d
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/29021711/
https://pubmed.ncbi.nlm.nih.gov/25881060/
https://pubmed.ncbi.nlm.nih.gov/19262553/

https://pubmed.ncbi.nlm.nih.gov/27228978/
https://www.hindawi.com/journals/omcl/2017/6473506/#B16
https://pubmed.ncbi.nlm.nih.gov/28903427/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Ginsenoside Rg1 Restores Sirt2/Foxo1 Expression and Alleviates Autism-Like Behaviors in a Valproic Acid Induced Male Mouse Model [ Kaohsiung J Med Sci, 2025, e70078.]	PubMed: 40622845
Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors [ iScience, 2024, 27(10):110862]	PubMed: 39319271
Effects of Bioactive Compound, Ginsenoside Rb1 on Burn Wounds Healing in Diabetic Rats: Influencing M1 to M2 Phenotypic Trans [ Waste Biomass Valori, 2024, 10.1007/s12649-023-02147-y]	PubMed: None
Ginsenoside Rg1 promotes astrocyte-to-neuron transdifferentiation in rat and its possible mechanism [ CNS Neurosci Ther, 2022, 10.1111/cns.14000]	PubMed: 36352836
Xuesaitong exerts long-term neuroprotection for stroke recovery by inhibiting the ROCKII pathway, in vitro and in vivo [ J Ethnopharmacol, 2021, S0378-8741(21)00169-0]	PubMed: 33617967

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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