Ginsenoside Rg1

製品コードS3923 バッチS392303

化学情報

	Synonyms	Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₄₂H₇₂O₁₄
	分子量	801.01	CAS No.	22427-39-0
Solubility (25°C)*	体外	DMSO	100 mg/mL (124.84 mM)
		Ethanol	100 mg/mL (124.84 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Ginsenoside Rg1 (Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1), one of the major active components of ginseng, is identified as a protopanaxatriol-type and has pharmacological actions such as neuroprotective and anti-tumor effects on various cancer types. Ginsenoside Rg1 reduces cerebral Aβ levels and NF-κB nuclear translocation.
in vitro	Ginsenoside Rg1 (Rg1) activates promyogenic kinases, p38MAPK (mitogen-activated protein kinase) and Akt signaling, that in turn promotes the heterodimerization with MyoD and E proteins, resulting in enhancing myogenic differentiation. Through the activation of Akt/mammalian target of rapamycin pathway, Rg1 induces myotube growth and prevents dexamethasone-induced myotube atrophy. Furthermore, Rg1 increases MyoD-dependent myogenic conversion of fibroblast. Rg1 enhances glucose uptake in insulin-resistant myoblasts^[1]. Rg1 possesses the capacity for anti-aging activity in HSCs both in vitro and vivo^[2]. Ginsenoside Rg1 promotes endothelial progenitor cells (EPCs) adhesion, proliferation, migration and in vitro vasculogenesis in a dose- and time-dependent manner^[3]. Ginsenoside Rg1 could prevent cellular apoptosis via initiating an autophagic survival response, during which time Rg1 could promote the expression of Beclin1 and Bcl-2 and weaken the interaction between Beclin1 and Bcl-2^[4].
in vivo	Rg1 can protect BMSCs against senescence and affect cell cycle phase distribution of bone marrow stromal cells (BMSCs) in aged rats. It affects inflammatory cytokine and stem cell factor (SCF) levels of BMSCs. Rg1 affects inflammatory cytokine and SCF levels of BMSCs. Rg1 improves the anti-aging ability of hematopoietic microenvironment through enhancing the anti-oxidant and anti-inflammatory capacities of BMSCs^[2]. Rg1 has neuroprotective properties in neurodegenerative diseases such as AD. Rg1 could ameliorate cognitive impairment in the mouse model of AD, improve the learning and memory abilities, decrease the levels of cerebral Aβ, maintain hippocampal neuron activity, and prevent cellular apoptosis induced by Aβ accumulation. On the other hand, Rg1 also could protect against brain aging by enhancing the scavenging of free radicals in the brain^[5].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Myoblast C2C12 cells
	濃度	1, 5, 10, 50 nM
	反応時間	2 days
	実験の流れ	For the induction of myogenic differentiation, C2C12 cells are exchanged from growth medium (GM) containing 15% FBS to differentiation medium (DM) containing 2% HS. The efficiency of the myoblast differentiation is quantified. To induce hypertrophic myoblast differentiation, C2C12 cells are differentiated for 2 d and then treated with Rg1 for additional 2 days in DM. For the DEX-induced atrophy study, C2C12 cells are triggered to differentiate for 24 hrs and treated with 25 μM DEX and 10 nM Rg1, followed by incubation in DM for 2 days.
動物実験	動物モデル	male Sprague-Dawley rats
	投薬量	20 mg/kg·d
	投与方法	i.p.

参考

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Ginsenoside Rg1 promotes astrocyte-to-neuron transdifferentiation in rat and its possible mechanism [ CNS Neurosci Ther, 2022, 10.1111/cns.14000]	PubMed: 36352836
Xuesaitong exerts long-term neuroprotection for stroke recovery by inhibiting the ROCKII pathway, in vitro and in vivo [ J Ethnopharmacol, 2021, S0378-8741(21)00169-0]	PubMed: 33617967

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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