GSH (Glutathione)

製品コードS4606 バッチS460603

化学情報

	Synonyms	Isethion, Glutathion, Tathion, L-Glutathione reduced, γ-L-Glutamyl-L-cysteinyl-glycine	Storage (From the date of receipt)	3 years -20°C(in the dark) powder
	化学式	C₁₀H₁₇N₃O₆S
	分子量	307.32	CAS No.	70-18-8
Solubility (25°C)*	体外	Water	46 mg/mL (149.68 mM)
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	GSH (Glutathione) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.
in vitro	Glutathione (GSH) is able to recover the meiotic failure induced by heavy metal cadmium (Cd) exposure through suppressing the excessive ROS level, DNA damage accumulation and apoptotic incidence in porcine oocytes.^[2]
in vivo	Oral glutathione (GSH) can increase its concentrations in several tissues following depletion.^[1]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	porcine oocytes
	濃度	1, 2 and 4 mM
	反応時間	--
	実験の流れ	Cadmium chloride is dissolved in PBS and diluted in TCM-199 medium to a final concentration of 0.4, 2, 10 and 50 μM, respectively. GSH (Glutathione) is dissolved in PBS and diluted in TCM-199 medium to a final concentration of 1, 2 and 4 mM, respectively. Both cadmium chloride and this compound are supplemented to TCM-199 medium immediately before culture.
動物実験	動物モデル	Mice (outbred albino ICR, 30-40 g)
	投薬量	100 mg/kg
	投与方法	oral administration

参考

https://pubmed.ncbi.nlm.nih.gov/1913980/
https://pubmed.ncbi.nlm.nih.gov/31520902/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

GPX4 deficiency-induced ferroptosis drives endometrial epithelial fibrosis in polycystic ovary syndrome [ Redox Biol, 2025, 83:103615]	PubMed: 40253746
Deep transfer learning approach for automated cell death classification reveals novel ferroptosis-inducing agents in subsets of B-ALL [ Cell Death Dis, 2025, 16(1):396]	PubMed: 40382332
IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming [ Elife, 2025, 13RP100406]	PubMed: 40299922
α-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4/SLC7A11/GPX4 signaling pathway [ Cell Mol Biol Lett, 2024, 29(1):88]	PubMed: 38877424
A Mechanistic Study of the Osteogenic Effect of Arecoline in an Osteoporosis Model: Inhibition of Iron Overload-Induced Osteogenesis by Promoting Heme Oxygenase-1 Expression [ Antioxidants (Basel), 2024, 13(4)430]	PubMed: 38671878
Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade [ Nat Commun, 2023, 14(1):4758]	PubMed: 37553341
Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade [ Nat Commun, 2023, 14(1):4758]	PubMed: 37553341
Piperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma via boosting oxidative stress-inflamation-CD8+-T cell immunity [ J Exp Clin Cancer Res, 2023, 42(1):118]	PubMed: 37161450
Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria [ Cell Rep, 2023, 42(9):113147]	PubMed: 37756158
Heat shock protein 27 deficiency promotes ferrous ion absorption and enhances acyl-Coenzyme A synthetase long-chain family member 4 stability to promote glioblastoma cell ferroptosis [ Cancer Cell Int, 2023, 23(1):5]	PubMed: 36639654

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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