Glycine

製品コードS4821 バッチS482103

印刷

化学情報

Chemical Structure Synonyms 2-Aminoacetic acid, Aminoacetic acid, Glycocoll Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C2H5NO2
分子量 75.07 CAS No. 56-40-6
Solubility (25°C)* 体外  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

生物活性

製品説明 Glycine (2-Aminoacetic acid, Aminoacetic acid, Glycocoll) is a non-essential, non-polar, non-optical, glucogenic amino acid that is primarily found in gelatin and silk fibroin. It is involved in the body's production of DNA, phospholipids and collagen, and in release of energy.
in vitro Glycine significantly increases the MG-63 cell proliferation in a dosedependent manner. Activity of alkaline phosphatase (ALP) and phosphorylation of extracellular-signal-regulated kinase are increased by glycine in MG-63 cells. Glycine also increases the BrdU-incorporation and Ki-67 mRNA expression in MCF-7 cells, induces the up-regulation of estrogen receptor-β mRNA expression and estrogen response element-luciferase activity in MG-63 and MCF-7 cells[2].
in vivo Glycine is the most abundant amino acid in the body and is involved in multiple metabolic pathways. Circulating glycine levels in humans, rats and mice, cats, and dogs range from 0.2-0.4 mM. In rabbits and pigs, they are 1-1.5 mM. Intracellular concentrations are much higher, particularly in renal proximal tubules, which reabsorb filtered glycine and reach 4–10x circulating levels depending on whether they are being actively perfused. Glycine has been reported to lower blood pressure in an NMDA-sensitive fashion[1]. Glycine has an estrogen-like osteoprotective effect in menopause models. It significantly increases the ALP activity, enhances bone mineral density, trabecular number, and connectivity density in OVX mice[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 MG-63 osteoblast cell line, MCF-7 estrogen-dependent cell line
濃度 0.1, 1, and 10 μg/ml
反応時間 48 h
実験の流れ

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動物実験 動物モデル Seven-week-old female Balb/c mice
投薬量 10 mg/kg
投与方法 orally

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Increased IRF9-STAT2 signaling leads to adaptive resistance toward targeted therapy in melanoma by restraining GSDME-dependent pyroptosis [ J Invest Dermatol, 2022, S0022-202X(22)00096-3] PubMed: 35148998
Uranium induces kidney cells pyroptosis in culture involved in ROS/NLRP3/caspase-1 signaling [ Free Radic Res, 2022, 1-13] PubMed: 35075949

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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