GsMTx4

製品コードP1205 バッチP120502

化学情報

	Synonyms		Storage (From the date of receipt)	3 years-20°C powder
	化学式	C₁₈₅H₂₇₃N₄₉O₄₅S₆
	分子量	4095.86	CAS No.	1209500-46-8
Solubility (25°C)*	体外	Water	82 mg/mL (20.02 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	GsMTx4 (Grammostola spatulata mechanotoxin 4, M-theraphotoxin-Gr1a, M-TRTX-Gr1a) is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families.
in vitro	Pretreatment of GsMTx4 and BAPTA-AM suppress the Yoda1-induced accumulation of HIF-1alpha, NFATC1, and NFATC3 proteins and also suppress Yoda1-induced VEGF-A expression at the mRNA and protein levels.^[2]
密度	95.0~105.0%

プロトコル(参考用のみ)

細胞アッセイ	細胞株	BMDMs, RAW264.7 cells
	濃度	5, 10 µM
	反応時間	30 min
	実験の流れ	To study the effect of mechanical stretching, BMDMs or RAW264.7 cells were treated with Yoda1, with or without pretreatment with inhibitors for 30 min. The inhibitors included cyclosporin A, FK506, echinomycin, GsMTx4, BAPTA-AM and RN-1734. In some experiments, BMDMs were treated with GSK1016790A. (Data sourced from selleck products)
動物実験	動物モデル	Male C57BL/6 mice
	投薬量	0.8 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/28076814/
https://pubmed.ncbi.nlm.nih.gov/35198061/
https://pubmed.ncbi.nlm.nih.gov/36455360/

https://pubmed.ncbi.nlm.nih.gov/35775626/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Targeting Piezo1 channel to alleviate intervertebral disc degeneration [ J Orthop Translat, 2025, 51:145-158]	PubMed: 40129609
Electroacupuncture attenuates intestinal epithelial ferroptosis in inflammatory bowel disease via Piezo1-mediated mitochondrial homeostasis [ Chin Med, 2025, 20(1):161]	PubMed: 41047414
Piezo1 regulates autophagy in HT22 hippocampal neurons through the Ca2+/Calpain and Calcineurin/TFEB signaling pathways [ PLoS One, 2025, 20(8):e0330282]	PubMed: 40857264
Low-intensity pulsed ultrasound promotes the osteogenesis of mechanical force-treated periodontal ligament cells via Piezo1 [ Front Bioeng Biotechnol, 2024, 12:1347406]	PubMed: 38694622
Low-intensity pulsed ultrasound promotes the osteogenesis of mechanical force-treated periodontal ligament cells via Piezo1 [ Front Bioeng Biotechnol, 2024, 12:1347406]	PubMed: 38694622
Piezo1 promotes peripheral nerve fibrotic scar formation through Schwann cell senescence [ Neurosci Lett, 2024, 837:137916]	PubMed: 39059459
PIEZO1 overexpression in hereditary hemorrhagic telangiectasia arteriovenous malformations [ bioRxiv, 2024, 2024.11.27.625696]	PubMed: 39651206
Enriched environment ameliorates fear memory impairments induced by sleep deprivation via inhibiting PIEZO1/calpain/autophagy signaling pathway in the basal forebrain [ CNS Neurosci Ther, 2023, 10.1111/cns.14365]	PubMed: 37485782
An EPHB4-RASA1 signaling complex inhibits shear stress-induced Ras-MAPK activation in lymphatic endothelial cells to promote the development of lymphatic vessel valves [ bioRxiv, 2023, 2023.11.22.568378]	PubMed: 38045382
Piezo1-mediated mechanosensation in bone marrow macrophages promotes vascular niche regeneration after irradiation injury [ Theranostics, 2022, 12(4): 1621-1638]	PubMed: N/A

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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