GW441756

製品コードS2891 バッチS289102

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₇H₁₃N₃O

分子量

275.3

CAS No.

504433-23-2

Solubility (25°C)*

体外

DMSO

27.5 mg/mL (99.89 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	10%DMSO 1 40%PEG300 2 5%Tween80 3 45%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.670mg/ml (2.43mM)	Taking the 1 mL working solution as an example, add 100 μL 6.67 mg/ml clear DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 450 μL ddH2O to make it clear. Volume up to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	13.000mg/ml (47.22mM)	Taking the 1 mL working solution as an example, add 50 μL of 260 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.600mg/ml (2.18mM)	Taking the 1 mL working solution as an example, add 50 μL of 12 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2. GW441756 produces a relevant increase of caspase-3 that leads to apoptosis.
in vitro	GW441756 can specifically block TrkA-induced cell death in a dose-dependent manner. This compound can block TrkA-mediated γH2AX production^[2]and apoptosis in TrkA-overexpressing cells. ^[3]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Cell-free assays
	濃度	2 nM
	反応時間
	実験の流れ
動物実験	動物モデル	Wistar male rats
	投薬量	10 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/15013000/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679291/
https://pubmed.ncbi.nlm.nih.gov/18511888/

https://pubmed.ncbi.nlm.nih.gov/32042328/

+ 展开

カスタマーフィードバック

: Data from [Data independently produced by , , Exp Neurol, 2018, 300:87-99]

: Data from [Data independently produced by , , Mol Cell Neurosci, 2016, 77:11-20.]

: Data from [Data independently produced by , , Int J Mol Med, 2018, 42(3):1484-1494]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells [ Cell Res, 2025, 10.1038/s41422-025-01098-4]	PubMed: 40122998
Neuronal FSTL4 negatively regulates BDNF-mediated neuron-glioma interaction [ Neurochem Int, 2025, 191:106072]	PubMed: 41082941
Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA [ Cells, 2023, 12(3)373]	PubMed: 36766714
Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA. Cells 2023, 12, 373 [ Cells, 2023, 12(3):373]	PubMed: None
The effect of Banxia-houpo decoction on CUMS-induced depression by promoting M2 microglia polarization via TrkA/Akt signalling [ J Cell Mol Med, 2023, 10.1111/jcmm.17906]	PubMed: 37581474
Huntingtin-associated protein 1 ameliorates neurological function rehabilitation by facilitating neurite elongation through TrKA-MAPK pathway in mice spinal cord injury [ Front Mol Neurosci, 2023, 16:1214150]	PubMed: 37609072
Huntingtin-associated protein 1 ameliorates neurological function rehabilitation by facilitating neurite elongation through TrKA-MAPK pathway in mice spinal cord injury [ Front Mol Neurosci, 2023, 16:1214150]	PubMed: 37609072
Wogonin, a Bioactive Ingredient from Huangqi Guizhi Formula, Alleviates Discogenic Low Back Pain via Suppressing the Overexpressed NGF in Intervertebral Discs [ Mediators Inflamm, 2023, 2023:4436587]	PubMed: 36860203
Propionibacterium acnes contributes to low back pain via upregulation of NGF in TLR2-NF-κB/JNK or ROS pathway [ Microbes Infect, 2022, S1286-4579(22)00050-8]	PubMed: 35430372
Sea urchin gangliosides exhibit neuritogenic effects in neuronal PC12 cells via TrkA- and TrkB-related pathways [ Biosci Biotechnol Biochem, 2021, 85(3):675-686]	PubMed: 33589896

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。