GYY4137

製品コードS9920 バッチS992001

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder, oxygen-free (long-term storage)
化学式

C11H16NO2PS2.C4H9NO
分子量 376.47 CAS No. 106740-09-4
Solubility (25°C)* 体外 DMSO 75 mg/mL (199.21 mM)
Water 5 mg/mL (13.28 mM)
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity.Stock solutions should be stored under nitrogen, sealed.
in vitro

GYY4137 (400-800 µM) causes concentration-dependent killing of seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS) but does not affect survival of normal human lung fibroblasts (IMR90, WI-38).[4]
in vivo

In the complete Freund's adjuvant (CFA)-treated mouse, GYY4137 injected 1 hr prior to CFA increased knee joint swelling while an anti-inflammatory effect, as demonstrated by reduced synovial fluid myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) activity and decreased TNF-α, IL-1β, IL-6 and IL-8 concentration, is apparent when this compound was injected 6 hrs after CFA.[3]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS
濃度 400 µM, 800 µM
反応時間 5 days, 8 days
実験の流れ

Live cell incubated with GYY4137(400 or 800 µM) are collected after 5 days and counted in triplicate after staining with trypan blue using a haemocytometer for cell viability assay. The generation of H2S from this compound is determined in aliquots (100 µl) withdrawn at timed intervals (up to 7 days) from cultured MCF-7 cells maintained in Dulbecco's modified Eagle's medium.
動物実験 動物モデル Complete Freund
投薬量 50 mg/kg
投与方法 i.p.

参考

  • https://pubmed.ncbi.nlm.nih.gov/18443240/
  • https://pubmed.ncbi.nlm.nih.gov/24535538/
  • https://pubmed.ncbi.nlm.nih.gov/23356870/
  • https://pubmed.ncbi.nlm.nih.gov/21701688/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Translocation of SIRT6 promotes glycolysis reprogramming to exacerbate diabetic angiopathy [ Redox Biol, 2025, 85:103736] PubMed: 40580755
Dietary sulfur amino acid restriction improves metabolic health by reducing fat mass [ Life Metab, 2025, 4(3):loaf009] PubMed: 40487564

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。