受注:045-509-1970 |
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | ||||
化学式 | C17H17N3O |
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分子量 | 279.34 | CAS No. | 941987-60-6 | ||||
Solubility (25°C)* | 体外 | DMSO | 56 mg/mL (200.47 mM) | ||||
Ethanol | 8 mg/mL (28.63 mM) | ||||||
Water | Insoluble | ||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | H-151 is a highly potent and covalent antagonist of STING that has noteworthy inhibitory activity both in human cells and in vivo. |
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in vivo | After intraperitoneal administration, H-151 reachs effective systemic levels, displays a short half-life in the serum and formed an adduct to mmSTING. Notably, pretreatment of H-151 markedly reduces systemic cytokine responses in CMA-treated mice. Moreover, H-151 exhibits notable efficacy in Trex1−/− mice that expressed a bioluminescent IFNβ reporter, when administered for one week.[1] |
細胞アッセイ | 細胞株 | FLDMs |
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濃度 | 25 µM | |
反応時間 | 12 h | |
実験の流れ | Cells were treated with indicated concentrations of drug. |
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動物実験 | 動物モデル | C57BL/6J mice |
投薬量 | 750 nM | |
投与方法 | i.p. |
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Inhibiting autophagy enhanced mitotic catastrophe-mediated anticancer immune responses by regulating the cGAS-STING pathway [ Cancer Lett, 2024, 586:216695] | PubMed: 38325769 |
Aryl hydrocarbon receptor suppresses STING-mediated type I IFN expression in triple-negative breast cancer [ Sci Rep, 2024, 14(1):5731] | PubMed: 38459088 |
Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity [ Int J Biol Sci, 2023, 19(3):981-993] | PubMed: 36778120 |
mascRNA alleviates STING-TBK1 signaling-mediated immune response through promoting ubiquitination of STING [ Mol Immunol, 2023, 154:45-53] | PubMed: 36603304 |
BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma [ Cancer Lett, 2022, 547:215885] | PubMed: 35995140 |
Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation [ Cell Rep, 2022, 41-1:111434] | PubMed: 36198273 |
WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC [ Cell Rep, 2022, 39(7):110814] | PubMed: 35584676 |
Manganese induces tumor cell ferroptosis through type-I IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase [ Free Radic Biol Med, 2022, 193(Pt 1):202-212] | PubMed: 36228830 |
SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways [ Mol Med, 2022, 28(1):125] | PubMed: 36273174 |
AKT1 Is Required for a Complete Palbociclib-Induced Senescence Phenotype in BRAF-V600E-Driven Human Melanoma [ Cancers (Basel), 2022, 14(3)572] | PubMed: 35158840 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。