H-151

製品コードS6652 バッチS665204

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₁₇H₁₇N₃O

分子量

279.34

CAS No.

941987-60-6

Solubility (25°C)*

体外

DMSO

56 mg/mL (200.47 mM)

Ethanol

14 mg/mL (50.11 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Clear solution

5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O

4.0mg/ml

Taking the 1 mL working solution as an example, add 50 μL of 80 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	H-151 is a highly potent and covalent antagonist of STING that has noteworthy inhibitory activity both in human cells and in vivo.
in vivo	After intraperitoneal administration, H-151 reachs effective systemic levels, displays a short half-life in the serum and formed an adduct to mmSTING. Notably, pretreatment of H-151 markedly reduces systemic cytokine responses in CMA-treated mice. Moreover, H-151 exhibits notable efficacy in Trex1−/− mice that expressed a bioluminescent IFNβ reporter, when administered for one week.^[1]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	FLDMs
	濃度	25 µM
	反応時間	12 h
	実験の流れ	Cells were treated with indicated concentrations of drug.
動物実験	動物モデル	C57BL/6J mice
	投薬量	750 nM
	投与方法	i.p.

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Inhibiting autophagy enhanced mitotic catastrophe-mediated anticancer immune responses by regulating the cGAS-STING pathway [ Cancer Lett, 2024, 586:216695]	PubMed: 38325769
Aryl hydrocarbon receptor suppresses STING-mediated type I IFN expression in triple-negative breast cancer [ Sci Rep, 2024, 14(1):5731]	PubMed: 38459088
Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity [ Int J Biol Sci, 2023, 19(3):981-993]	PubMed: 36778120
mascRNA alleviates STING-TBK1 signaling-mediated immune response through promoting ubiquitination of STING [ Mol Immunol, 2023, 154:45-53]	PubMed: 36603304
BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma [ Cancer Lett, 2022, 547:215885]	PubMed: 35995140
Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation [ Cell Rep, 2022, 41-1:111434]	PubMed: 36198273
WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC [ Cell Rep, 2022, 39(7):110814]	PubMed: 35584676
Manganese induces tumor cell ferroptosis through type-I IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase [ Free Radic Biol Med, 2022, 193(Pt 1):202-212]	PubMed: 36228830
SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways [ Mol Med, 2022, 28(1):125]	PubMed: 36273174
AKT1 Is Required for a Complete Palbociclib-Induced Senescence Phenotype in BRAF-V600E-Driven Human Melanoma [ Cancers (Basel), 2022, 14(3)572]	PubMed: 35158840

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。