H-151

製品コードS6652 バッチS665204

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₁₇H₁₇N₃O

分子量

279.34

CAS No.

941987-60-6

Solubility (25°C)*

体外

DMSO

56 mg/mL (200.47 mM)

Ethanol

14 mg/mL (50.11 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	4.000mg/ml (14.32mM)	Taking the 1 mL working solution as an example, add 50 μL of 80 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	H-151 is a highly potent and covalent antagonist of STING that has noteworthy inhibitory activity both in human cells and in vivo.
in vivo	After intraperitoneal administration, H-151 reachs effective systemic levels, displays a short half-life in the serum and formed an adduct to mmSTING. Notably, pretreatment of this compound markedly reduces systemic cytokine responses in CMA-treated mice. Moreover, it exhibits notable efficacy in Trex1−/− mice that expressed a bioluminescent IFNβ reporter, when administered for one week.^[1]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	FLDMs
	濃度	25 µM
	反応時間	12 h
	実験の流れ	Cells were treated with indicated concentrations of this compound.
動物実験	動物モデル	C57BL/6J mice
	投薬量	750 nM
	投与方法	i.p.

参考

https://www.ncbi.nlm.nih.gov/pubmed/?term=Targeting+STING+with+covalent+small-molecule+inhibitors
https://pubmed.ncbi.nlm.nih.gov/36198273/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Irisin-mediated muscle-renal crosstalk as a protective mechanism against contrast-induced acute kidney injury via cGAS-STING signalling inhibition [ Clin Transl Med, 2025, 15(3):e70235]	PubMed: 40008481
TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD [ J Neuroinflammation, 2025, 22(1):14]	PubMed: 39844196
CAD hijacks STING to impair antitumor immunity and radiotherapy efficacy of colorectal cancer [ Cell Death Dis, 2025, 16(1):641]	PubMed: 40849416
Development of a TBK1 and ALK dual inhibitor for alleviating depressive behavior via anti-inflammatory effects [ Biomed Pharmacother, 2025, 186:117991]	PubMed: 40117902
EZH2 inhibits senescence-associated inflammation and attenuates intervertebral disc degeneration by regulating the cGAS/STING pathway via H3K27me3 [ Osteoarthritis Cartilage, 2025, S1063-4584(25)00796-4]	PubMed: 39938633
LAPTM5 exacerbates STING-mediated inflammation induced by LL-37 through stabilizing STING in rosacea [ Commun Biol, 2025, 8(1):1470]	PubMed: 41087666
Profile of STING agonist and inhibitor research: a bibliometric analysis [ Front Pharmacol, 2025, 16:1528459]	PubMed: 40008133
Brazilin Inhibits the Proliferation of Non-Small Cell Lung Cancer by Regulating the STING/TBK1/IRF3 Pathway [ J Cell Mol Med, 2025, 29(13):e70688]	PubMed: 40596709
Ciprofloxacin enhances RSL3-induced ferroptosis by promoting mitochondrial Zn2+ accumulation via the STING1-CAV2 pathway [ J Biol Chem, 2025, 301(10):110653]	PubMed: 40889676
STING orchestrates the neuronal inflammatory stress response in multiple sclerosis [ Cell, 2024, 187(15):4043-4060.e30.]	PubMed: 38878778

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。