Hexachlorophene

製品コードS4632 バッチS463201

化学情報

	Synonyms	Hexachlorofen, Fostril, Nabac, pHisoHex	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₃H₆Cl₆O₂
	分子量	406.90	CAS No.	70-30-4
Solubility (25°C)*	体外	DMSO	81 mg/mL (199.06 mM)
		Ethanol	81 mg/mL (199.06 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Hexachlorophene (Hexachlorofen, Fostril, Nabac, pHisoHex) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; It can also attenuate Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
in vitro	Hexachlorophene, the active component of a prescription drug, as a potent KCNQ channel activator with unique subtype selectivity. It exhibits strong potentiation effects on both the homomeric KCNQ1 and the KCNQ1/KCNE1 complex. HCP potently increases the current amplitude of KCNQ1/KCNE1 expressed by stabilizing the channel in an open state with an EC50 of 4.61±1.29 μM. HCP significantly shortens the action potential duration at 1 μM in cardiomyocytes. In addition, HCP is capable of rescuing the loss of function of the LQTs mutants caused by either impaired activation gating or phosphatidylinositol-4,5-bisphosphate (PIP2) binding affinity^[1].

製品説明

Hexachlorophene (Hexachlorofen, Fostril, Nabac, pHisoHex) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; It can also attenuate Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

in vitro

Hexachlorophene, the active component of a prescription drug, as a potent KCNQ channel activator with unique subtype selectivity. It exhibits strong potentiation effects on both the homomeric KCNQ1 and the KCNQ1/KCNE1 complex. HCP potently increases the current amplitude of KCNQ1/KCNE1 expressed by stabilizing the channel in an open state with an EC50 of 4.61±1.29 μM. HCP significantly shortens the action potential duration at 1 μM in cardiomyocytes. In addition, HCP is capable of rescuing the loss of function of the LQTs mutants caused by either impaired activation gating or phosphatidylinositol-4,5-bisphosphate (PIP2) binding affinity^[1].

プロトコル(参考用のみ)

参考

[1] Zheng Y, et al. PLoS One. 2012, 7(12):e51820.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways [ Toxicol Appl Pharmacol, 2022, 441:115988]	PubMed: 35307375
The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation [ Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.04.011]	PubMed: 31155509

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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