4'-Hydroxychalcone

製品コードS4937 バッチS493702

印刷

化学情報

Synonyms

P-Cinnamoylphenol

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₅H₁₂O₂

分子量

224.25

CAS No.

2657-25-2

Solubility (25°C)*

体外

DMSO

44 mg/mL (196.2 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	4'-Hydroxychalcone (P-Cinnamoylphenol), found in herbs and spices and tea, is a member of the class of compounds known as retrochalcones. It has diverse biological activities, inhibiting TNFα-induced NF-κB pathway activation in a dose-dependent manner and activating BMP signaling.
in vitro	The oxidation to 4′-hydroxychalcone was catalyzed by CYP 1A1 and 2C6. It shows estrogenic activity^[1]. 4'-hydroxychalcone inhibits TNFα-induced NF-kB pathway activation in a dose-dependent manner. It inhibits TNFα-dependent degradation of IkBα and subsequently prevents p50/p65 nuclear translocation leading to 40-hydroxychalcone-inhibited expression of NF-kB target genes. Inhibition of NF-kB activation by 4'-hydroxychalcone is not leukemia cell-type specific and has no significant effect on non-transformed cell viability. 26S proteasome is a major molecular target of 4'-hydroxychalcone^[2].

製品説明

4'-Hydroxychalcone (P-Cinnamoylphenol), found in herbs and spices and tea, is a member of the class of compounds known as retrochalcones. It has diverse biological activities, inhibiting TNFα-induced NF-κB pathway activation in a dose-dependent manner and activating BMP signaling.

in vitro

The oxidation to 4′-hydroxychalcone was catalyzed by CYP 1A1 and 2C6. It shows estrogenic activity^[1]. 4'-hydroxychalcone inhibits TNFα-induced NF-kB pathway activation in a dose-dependent manner. It inhibits TNFα-dependent degradation of IkBα and subsequently prevents p50/p65 nuclear translocation leading to 40-hydroxychalcone-inhibited expression of NF-kB target genes. Inhibition of NF-kB activation by 4'-hydroxychalcone is not leukemia cell-type specific and has no significant effect on non-transformed cell viability. 26S proteasome is a major molecular target of 4'-hydroxychalcone^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	K562 cells
	濃度	20, 24, 28, 32, 40 μM
	反応時間	2 h
	実験の流れ	K562 cells are treated with 4'-hydroxychalcone at the different concentrations for 2 h followed by a TNFα-treatment (20 ng/mL) during 6 h.

参考

https://pubmed.ncbi.nlm.nih.gov/15863696/
https://pubmed.ncbi.nlm.nih.gov/21703248/

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。