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Synonyms | Venglustat succinate | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C20H24FN3O2S.C4H6O5 |
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分子量 | 523.58 | CAS No. | 1629063-78-0 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (190.99 mM) | |
Water | 100 mg/mL (190.99 mM) | |||
Ethanol | 100 mg/mL (190.99 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Ibiglustat succinate (Venglustat succinate) is a glucosylceramide (GlcCer) synthase inhibitor that blocks the formation of glucosylceramide. |
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in vitro | Ibiglustat succinate can prevent additional globotriaosylceramide(GL-3) accumulation and could serve to ameliorate the abundant levels of this sphingolipid in fabry disease cardiomyocytes.[2] |
in vivo | Venglustat administration signifcantly reduces the accumulation of glycosphingolipids and pathological α-synuclein aggregates in the central nervous system and ameliorated the associated memory defcit. [3] |
細胞アッセイ | 細胞株 | Fabry disease cardiomyocytes |
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濃度 | 1 μM | |
反応時間 | 15 days | |
実験の流れ | Embryoid bodies (EBs) are treated with 1 μM Ibiglustat succinate for 15 days. Culture medium with Ibiglustat succinate is replaced every 2 days during the 15 days of treatment. GL-3 clearance is tested once the GL3 accumulation reached the plateau. Twenty-eight days after the start of differentiation, beating EBs are treated with 1 μM of Ibiglustat succinate for 15 days or with 0.3 μg/ml of agalsidase beta for 5 days. Culture media with Ibiglustat succinate or agalsidase beta are replaced every 2 days. GL-3 accumulation is investigated by immunocytological (ICC), electron microscopy (EM), and mass spectrometry (MS) analysis. |
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動物実験 | 動物モデル | Gaucher disease model mice(C57Bl/6) |
投薬量 | 0.03%, 0.033% | |
投与方法 | p.o. |
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Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD [ Cell Rep, 2023, 42(12):113431] | PubMed: 38039961 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。