Imipramine HCl

製品コードS4377 バッチS437702

印刷

化学情報

Chemical Structure Synonyms Melipramine HCl,G 22355 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C19H25ClN2
分子量 316.87 CAS No. 113-52-0
Solubility (25°C)* 体外 DMSO 63 mg/mL (198.81 mM)
Water 63 mg/mL (198.81 mM)
Ethanol 63 mg/mL (198.81 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明 Imipramine (Melipramine,G 22355) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).
in vitro

Imipramine in the microsomal incubation results in a predicted value for human clearance of 8.6 to 11 ml/min/kg, a slight underestimate of reported mean human blood clearance values (14–15 ml/min/kg). [1] Imipramine is metabolized into N-desmethylimipramine (84%), 2-hydroxyimipramine (10%), and 10-hydroxyimipramine (6%) in human hepatic microsomes. [2] Imipramine (3 μM) inhibits HERG-encoded potassium channels in a reversible manner in CHO cells. Imipramine (3 μM) inhibits HERG tail currents (IHERG) following test pulses to +20 mV with an IC50 of 3.4 μM and a Hill coefficient of 1.17 in CHO cells. Imipramine can completely block native cardiac IKr at 1μm in guinea-pig myocytes. [3]
in vivo

Imipramine (10 mg/kg b.i.d.) reverses the decreased sucrose intake of rats exposed to chronic mild stress. Imipramine (10 mg/kg b.i.d.) completely reverses stress caused decrease in D2-receptor binding in the limbic forebrain (but not the striatum). [4] Imipramine (15 mg/kg, IP) exerts anxiolytic-like effects in the two elevated T-maze tasks in male Wistar rats. Imipramine (15 mg/kg, IP) enhances both avoidance and escape latencies in male Wistar rats. Imipramine (15 mg/kg, IP) decreases locomotor activity measured in a square arena in male Wistar rats. [5]

プロトコル(参考用のみ)

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Role of extracellular vesicles secretion in paclitaxel resistance of prostate cancer cells [ Cancer Drug Resist, 2022, 5(3):612-624] PubMed: 36176762
Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia [ Antioxidants (Basel), 2021, 10(6)956] PubMed: 34203664

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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