Indoximod

製品コードS7756 バッチS775604

印刷

化学情報

Synonyms

NLG-8189, 1-Methyl-D-tryptophan, 1-MT

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₂H₁₄N₂O₂

分子量

218.25

CAS No.

110117-83-4

Solubility (25°C)*

体外

0.1M NaOH

11 mg/mL (50.4 mM)

DMSO (warmed with 50ºC water bath)

1 mg/mL (4.58 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Indoximod, a methylated tryptophan, acts as an IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor, and reverses IDO-mediated immune suppression. Phase 2.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
in vitro	Indoximod significantly reverses the suppression of T cells created by IDO-expressing dendritic cells, using both human monocyte-derived dendritic cells and murine dendritic cells isolated directly from tumor-draining lymph nodes. ^[1] This compound activates a Trp sufficiency signal that stimulates mTOR, and relieves IDO-induced Trp deprivation as well as an autophagic response. ^[2]
in vivo	In mouse models of transplantable melanoma and transplantable and autochthonous breast cancer, Indoximod (400 mg/kg p.o.) enhances antitumor immunity in the setting of combined chemo-immunotherapy regimens. ^[1]

プロトコル(参考用のみ)

動物実験	動物モデル	Mouse B16F10 and 4T1 tumor models
	投薬量	400 mg/kg
	投与方法	p.o.

参考

https://pubmed.ncbi.nlm.nih.gov/17234791/
https://pubmed.ncbi.nlm.nih.gov/23264892/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Host-functionalization of macrin nanoparticles to enable drug loading and control tumor-associated macrophage phenotype [ Front Immunol, 2024, 15:1331480]	PubMed: 38545103
Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors [ iScience, 2024, 27(10):110862]	PubMed: 39319271
Bridging of host-microbiota tryptophan partitioning by the serotonin pathway in fungal pneumonia [ Nat Commun, 2023, 14(1):5753]	PubMed: 37717018
Bridging of host-microbiota tryptophan partitioning by the serotonin pathway in fungal pneumonia [ Nat Commun, 2023, 14(1):5753]	PubMed: 37717018
Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation [ J Immunother Cancer, 2021, 9(7)e002840]	PubMed: 34326168
Indoleamine 2, 3-dioxygenase 1 aggravates acetaminophen-induced acute liver failure by triggering excess nitroxidative stress and iron accumulation [ Free Radic Biol Med, 2021, S0891-5849(21)00407-X]	PubMed: 34242792
Decreased IDO1 Dependent Tryptophan Metabolism in Aged Lung during Influenza [ Eur Respir J, 2020, 2000443]	PubMed: 33243840
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer [ Elife, 2020, 9e56749]	PubMed: 33016874
Early myeloid-derived suppressor cells (HLA-DR-/lowCD33+CD16-) expanded by granulocyte colony-stimulating factor prevent acute graft-versus-host disease (GVHD) in humanized mouse and might contribute to lower GVHD in patients post allo-HSCT. [ J Hematol Oncol, 2019, 12(1):31]	PubMed: 30885244
TLR7/8-agonist-loaded Nanoparticles Promote the Polarization of Tumour-Associated Macrophages to Enhance Cancer Immunotherapy [ Nat Biomed Eng, 2018, 2(8):578-588]	PubMed: 31015631

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。