Insulin (human)

製品コードS6955 バッチS695502

化学情報

	Synonyms	Insulin regular	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₂₅₇H₃₈₃N₆₅O₇₇S₆
	分子量	5807.57	CAS No.	11061-68-0
Solubility (25°C)*	体外	0.01M HCl	13 mg/mL warmed with 50ºC water bath (2.23 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Insulin (human) (Insulin regular) is a polypeptide hormone that regulates the level of glucose. Insulin is commonly used to treat hyperglycemia in patients with diabetes. Potency: 29 units/mg.
in vitro	Insulin (human), an inducer of AKT phosphorylation, reduces the levels of LC3-II, VP1 by the AKT-AMPKMAPK-MTOR pathway in SVV-infected cells.^[2]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	BHK-21 cells and PK-15 cells
	濃度	200 ng/ml
	反応時間	1 h
	実験の流れ	BHK-21 cells and PK-15 cells are grown to 80% confluence in well plates and pretreated with insulin (human) (200 ng/ml) for 1 h. The pretreated cells are then infected with SVV for 1 h. The cells are then washed with phosphate-buffered saline (PBS) and incubated with new medium containing the same chemical reagents. Cell viability in the presence of this compound is tested.

参考

https://pubmed.ncbi.nlm.nih.gov/26537234/
https://pubmed.ncbi.nlm.nih.gov/34757844/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation [ Cell Biosci, 2025, 15(1):4]	PubMed: 39825425
Spermine attenuates TGF-β-induced EMT by downregulating fibronectin [ J Biol Chem, 2025, S0021-9258(25)00201-7]	PubMed: 40015634
Vorinostat attenuates UVB-induced skin senescence by modulating NF-κB and mTOR signaling pathways [ Sci Rep, 2025, 15(1):10905]	PubMed: 40158057
ALKBH5 governs human endoderm fate by regulating the DKK1/4-mediated Wnt/β-catenin activation [ Nucleic Acids Res, 2024, gkae707]	PubMed: 39166492
Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity [ Discov Oncol, 2023, 14(1):139]	PubMed: 37498338
Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity [ Discov Oncol, 2023, 14(1):139]	PubMed: 37498338
EGFR/MET promotes hepatocellular carcinoma metastasis by stabilizing tumor cells and resisting to RTKs inhibitors in circulating tumor microemboli [ Cell Death Dis, 2022, 13(4):351]	PubMed: 35428350
Somatostatin receptor ligands suppressed proliferation and lipogenesis in 3T3-L1 preadipocytes [ Basic Clin Pharmacol Toxicol, 2022, 131(3):174-188]	PubMed: 35688794
PI3K/AKT1 Signaling Pathway Mediates Sinomenine-Induced Hepatocellular Carcinoma Cells Apoptosis: An in Vitro and in Vivo Study [ Biol Pharm Bull, 2022, 45(5):614-624]	PubMed: 35491166
Synergetic contributions of viral VP1, VP3, and 3C to activation of the AKT-AMPK-MAPK-MTOR signaling pathway for Seneca Valley virus-induced autophagy [ J Virol, 2021, JVI0155021]	PubMed: 34757844

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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