Insulin (human)

製品コードS6955 バッチS695504

印刷

化学情報

Chemical Structure Synonyms Insulin regular Storage
(From the date of receipt)		 3 years -20°C powder
化学式

C257H383N65O77S6
分子量 5807.57 CAS No. 11061-68-0
Solubility (25°C)* 体外 DMSO 100 mg/mL (17.21 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Insulin (human) (Insulin regular) is a polypeptide hormone that regulates the level of glucose. Insulin is commonly used to treat hyperglycemia in patients with diabetes. Potency: 29 units/mg.
in vitro

Insulin (human), an inducer of AKT phosphorylation, reduces the levels of LC3-II, VP1 by the AKT-AMPKMAPK-MTOR pathway in SVV-infected cells.[2]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 BHK-21 cells and PK-15 cells
濃度 200 ng/ml
反応時間 1 h
実験の流れ

BHK-21 cells and PK-15 cells are grown to 80% confluence in well plates and pretreated with insulin (human) (200 ng/ml) for 1 h. The pretreated cells are then infected with SVV for 1 h. The cells are then washed with phosphate-buffered saline (PBS) and incubated with new medium containing the same chemical reagents. Cell viability in the presence of this compound is tested.

参考

  • https://pubmed.ncbi.nlm.nih.gov/26537234/
  • https://pubmed.ncbi.nlm.nih.gov/34757844/

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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