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Synonyms | CPT-11 hydrochloride, (+)-Irinotecan hydrochloride | Storage (From the date of receipt) |
3 years -20°C powder | ||||||||
化学式 | C33H39ClN4O6 |
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分子量 | 623.14 | CAS No. | 100286-90-6 | ||||||||
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (160.47 mM) | ||||||||
Water | Insoluble | ||||||||||
Ethanol | Insoluble | ||||||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Irinotecan (CPT-11, (+)-Irinotecan) hydrochloride is an inhibitor of Topoisomerase I (Topo I) that exhibits cytotoxicity in LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. |
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in vitro | The combination of gefitinib and irinotecan has a significant synergistic effect on the proliferation and migration of MDA-MB-231 cells.[2] |
in vivo | The combination of gefitinib and irinotecan has a significant synergistic effect in the treatment of TNBC subtype cells in xenograft model.[2] |
細胞アッセイ | 細胞株 | Human BC cell lines |
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濃度 | 32 μM | |
反応時間 | 24 h, 72 h | |
実験の流れ | Cells are seeded in 96-well plates at 6 × 103 cells/well for overnight incubation. The cells are exposed to irinotecan alone or combinations. Seventy-two hours after drug treatment, cell viability is tested with the MTT assay. For wound fealing assay, cells are seeded in 6-well culture plates at a density of 3 × 105 cells/mL. After growing to confluence, cells are treated with irinotecan for 48 h in DMEM. |
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動物実験 | 動物モデル | Female BALB/c nude mice bearing MDA-MB-231 cells |
投薬量 | 8 mg/kg | |
投与方法 | i.p. |
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Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer [ Drug Resist Updat, 2023, 71:101005] | PubMed: 37647746 |
A novel TOX3-WDR5-ABCG2 signaling axis regulates the progression of colorectal cancer by accelerating stem-like traits and chemoresistance [ PLoS Biol, 2023, 21(9):e3002256] | PubMed: 37708089 |
A novel TOX3-WDR5-ABCG2 signaling axis regulates the progression of colorectal cancer by accelerating stem-like traits and chemoresistance [ PLoS Biol, 2023, 21(9):e3002256] | PubMed: 37708089 |
HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1 [ J Cancer, 2023, 10.7150/jca.87545] | PubMed: 37781079 |
HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1 [ J Cancer, 2023, 14(15):2820-2832] | PubMed: 37781079 |
Colorectal Cancer Patient-Derived 2D and 3D Models Efficiently Recapitulate Inter- and Intratumoral Heterogeneity [ Adv Sci (Weinh), 2022, e2201539] | PubMed: 35652270 |
Inhibition of Heme Export and/or Heme Synthesis Potentiates Metformin Anti-Proliferative Effect on Cancer Cell Lines [ Cancers (Basel), 2022, 14(5)1230] | PubMed: 35267538 |
coupled Hydrodynamic Flow Focusing (cHFF) to Engineer Lipid-Polymer Nanoparticles (LiPoNs) for Multimodal Imaging and Theranostic Applications [ Biomedicines, 2022, 10(2)438] | PubMed: 35203647 |
K-Ras and p53 mouse model with molecular characteristics of human rhabdomyosarcoma and translational applications [ Dis Model Mech, 2022, 15-2dmm049004] | PubMed: 35174853 |
Integrated genome and tissue engineering enables screening of cancer vulnerabilities in physiologically relevant perfusable ex vivo cultures [ Biomaterials, 2021, 280:121276] | PubMed: 34890975 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。