Isoquercitrin

製品コードS3842 バッチS384201

印刷

化学情報

Synonyms

Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₁H₂₀O₁₂

分子量

464.38

CAS No.

482-35-9

Solubility (25°C)*

体外

DMSO

92 mg/mL (198.11 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Bidens bipinnata Lから単離された抗がん活性を持つフラボノイド化合物であるIsoquercitrin（Hirsutrin、3-Glucosylquercetin、Quercetin 3-o-glucopyranoside）は、β-カテニン核内移行の下流で作用するWnt/β-カテニンの阻害剤です。
in vitro	Isoquercitrin exerts inhibitory effect on Wnt/β-catenin signaling and no toxic effects on colon cancer cell lines. It supresses the proliferation of colon cancer cells but does not affect non-tumoral colon cells. This compound inhibits cell migration in colon cancer cells, but has also no apparent effect on the non-tumor colon cells. It inhibits the signaling downstream of β-catenin nuclear translocation as this chemical reverses the effect of β-catenin S33A, which cannot be phosphorylated and avoids degradation.
in vivo	Isoquercitrin treatment significantly affects Xenopus embryo development, most likely by disturbing axial patterning. This compound affects canonical Wnt signaling downstream of β-Catenin nucleus translocation. In animals receiving this chemical, eosinophil counts are lower in the bronchoalveolar lavage fluid (BALF), blood and lung pa-renchyma. Neutrophil counts in blood and IL-5 levels in lung homogenate are lower in treated mice. No alterations in mononuclear cell numbers are observed. It also demonstrates anti-asthmatic activity by inhibiting of carbachol- and leukotriene D4-induced contraction in guinea pig airways.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	HCT-116 cells
	濃度	75 and 150 μM
	反応時間	24 h
	実験の流れ	HCT-116 cells are treated with flavonoid isoquercitrin for 24 h at concentrations of 75 and 150 μM. DMSO (used as a vehicle to solubilize the flavonoids) is added to control cultures at 1% v/v. To stimulate the Wnt pathway, cells are treated with Wnt3a-conditioned medium (CM) for 6 h at 25% of conditioned medium. Cells are co-treated with Wnt3a-CM and this compound for 6 h at 75 or 150 μM.
動物実験	動物モデル	a murine model of asthma (Female BALB/c mice)
	投薬量	15 mg/kg
	投与方法	by oral gavage

参考

https://pubmed.ncbi.nlm.nih.gov/25359775/
https://pubmed.ncbi.nlm.nih.gov/18026696/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Anti-Glycation Activities of Angelica keiskei Leaves [ Molecules, 2025, 30(6)1394]	PubMed: 40142168
Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling [ Commun Biol, 2023, 6(1):79]	PubMed: 36681760
Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy [ Front Pharmacol, 2023, 14:1290868]	PubMed: 38313075
Periostin promotes nucleus pulposus cells apoptosis by activating the Wnt/β-catenin signaling pathway [ FASEB J, 2022, 36(7):e22369]	PubMed: 35747912
Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment [ Cancers (Basel), 2021, 13(16)4200]	PubMed: 34439352
The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts [ Signal Transduct Target Ther, 2019, 4:63]	PubMed: 31885878

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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