Jaceosidin

製品コードS0931 バッチS093101

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₁₇H₁₄O₇

分子量

330.29

CAS No.

18085-97-7

Solubility (25°C)*

体外

DMSO

66 mg/mL (199.82 mM)

Ethanol

6 mg/mL (18.16 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Jaceosidin, a flavonoid isolated from Artemisia vestita, possesses anti-tumor and anti-proliferative activities in many cancer cells. Jaceosidin induces apoptosis, activates Bax and down-regulates Mcl-1 and c-FLIP expression. Jaceosidin inhibits COX-2 expression and NF-κB activation.
in vitro	This compound induces apoptosis through Bax activation and downregulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells.^[1]
in vivo	Jaceosidin blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates, inhibits COX-2 expression and NF-kappaB activation, and markedly reduces TNF-alpha, IL-1beta, and prostaglandin E2 (PGE(2)) levels, also inhibits hind paw edema induced by carrageenan.^[2]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Human renal carcinoma (Caki, ACHN, A498, and 786-O cell lines)
	濃度	--
	反応時間	--
	実験の流れ	Caki cells were treated with 75 µM jaceosidin for 3 h. The mitochondrial membrane potential (MMP) was measured using a flow cytometer. Caki cells were treated with 75 µM this compound for 12 and 24 h. Cytoplasmic fractions were analyzed for cytochrome c release. Caki cells were treated 75 µM this chemical for 1, 3, 6 h and stained for active Bax using conformation-specific antibodies. The fluorescence intensity was detected by flow cytometry. For the Bax oligomerization assay, Caki cells were treated with 75 µM this agent for 1, 3, 6 h. After treatment, Bax monomers and oligomers were detected by western blotting.
動物実験	動物モデル	mice of air pouch model of inflammation, rats of paw edema model of inflammation
	投薬量	10, 20 mg/kg
	投与方法	p.o., s.c.

参考

https://pubmed.ncbi.nlm.nih.gov/27729209/
https://pubmed.ncbi.nlm.nih.gov/19505561/

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。