Jaceosidin

製品コードS0931 バッチS093101

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₁₇H₁₄O₇
	分子量	330.29	CAS No.	18085-97-7
Solubility (25°C)*	体外	DMSO	66 mg/mL (199.82 mM)
		Ethanol	6 mg/mL (18.16 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Jaceosidin, a flavonoid isolated from Artemisia vestita, possesses anti-tumor and anti-proliferative activities in many cancer cells. Jaceosidin induces apoptosis, activates Bax and down-regulates Mcl-1 and c-FLIP expression. Jaceosidin inhibits COX-2 expression and NF-κB activation.
in vitro	Jaceosidin induces apoptosis through Bax activation and downregulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells.^[1]
in vivo	Jaceosidin blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates, inhibits COX-2 expression and NF-kappaB activation, and markedly reduces TNF-alpha, IL-1beta, and prostaglandin E2 (PGE(2)) levels, also inhibits hind paw edema induced by carrageenan.^[2]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Human renal carcinoma (Caki, ACHN, A498, and 786-O cell lines)
	濃度	--
	反応時間	--
	実験の流れ	Caki cells were treated with 75 µM jaceosidin for 3 h. The mitochondrial membrane potential (MMP) was measured using a flow cytometer. Caki cells were treated with 75 µM jaceosidin for 12 and 24 h. Cytoplasmic fractions were analyzed for cytochrome c release. Caki cells were treated 75 µM jaceosidin for 1, 3, 6 h and stained for active Bax using conformation-specific antibodies. The fluorescence intensity was detected by flow cytometry. For the Bax oligomerization assay, Caki cells were treated with 75 µM jaceosidin for 1, 3, 6 h. After treatment, Bax monomers and oligomers were detected by western blotting.
動物実験	動物モデル	mice of air pouch model of inflammation, rats of paw edema model of inflammation
	投薬量	10, 20 mg/kg
	投与方法	p.o., s.c.

参考

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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