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Synonyms | KGN | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C20H15NO3 |
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分子量 | 317.34 | CAS No. | 4727-31-5 | |
Solubility (25°C)* | 体外 | DMSO | 63 mg/mL (198.52 mM) | |
Ethanol | 5 mg/mL warmed with 50ºC water bath (15.75 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. |
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in vitro | Kartogenin induces chondrocyte differentiation from hMSCs by enhancing the nuclear localization of CBFβ, and protects articular chondrocytes. [1] Kartogenin promotes the type-I collagen synthesis of dermal fibroblasts via activation of the smad4/smad5 pathway without obvious cytotoxicity on fibroblasts’ viability, morphology and survival. [2] |
in vivo | Kartogenin promotes cartilage repair in collagenase VII (10 μM)– and surgery (100 μM)-induced OA models in mice. [1] Kartogenin (100 nM) also stimulats collagen synthesis in the mouse dermis. [2] In addition, Kartogenin stimulates mouse limb skeletal growth and synovial joint development. [3] |
細胞アッセイ | 細胞株 | Fibroblasts |
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濃度 | ~1 μM | |
反応時間 | 48 hours | |
実験の流れ | For the cell viability assay, fibroblasts are seeded on six-well plates, followed by Kartogenin or DMSO treatment. According to the manufacturer’s instructions, cell viability and viability are assessed by AlamarBlue assay. | |
動物実験 | 動物モデル | Collagenase VII-induced OA mouse model and Surgery-induced OA mouse model |
投薬量 | 10 μM or 100 μM | |
投与方法 | Intra-articular injection |
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Fabrication of Injectable Kartogenin-Conjugated Composite Hydrogel with a Sustained Drug Release for Cartilage Repair [ Pharmaceutics, 2023, 15(7)1949] | PubMed: 37514135 |
An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration [ Int J Mol Sci, 2022, 24(1)390] | PubMed: 36613833 |
Construction of Biocompatible Hydrogel Scaffolds With a Long-Term Drug Release for Facilitating Cartilage Repair [ Front Pharmacol, 2022, 13:922032] | PubMed: 35784682 |
Kartogenin Improves Osteogenesis of Bone Marrow Mesenchymal Stem Cells via Autophagy [ Stem Cells Int, 2022, 2022:1278921] | PubMed: 36591373 |
A chondrogenesis induction system based on a functionalized hyaluronic acid hydrogel sequentially promoting hMSC proliferation, condensation, differentiation, and matrix deposition [ Acta Biomater, 2021, S1742-7061(21)00015-5] | PubMed: 33444801 |
Kartogenin Inhibits Prostate Cancer Cell Growth Through Smad2 Activation and Decreases Androgen Receptor Nuclear Localization [ Anticancer Res, 2021, 41(10):4753-4759] | PubMed: 34593424 |
Intra-articular Injection of Kartogenin-Incorporated Thermogel Enhancing Osteoarthritis Treatment. [ Front Chem, 2019, 7:677] | PubMed: 31681730 |
Effects of kartogenin on the attenuated nucleus pulposus cell degeneration of intervertebral discs induced by interleukin-1β and tumor necrosis factor-α [ Int J Mol Med, 2018, 41(2):749-756] | PubMed: 29207013 |
Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance. [Duffy DJ, et al. Genome Med, 2017, 10.1186/s13073-017-0407-3] | PubMed: 28187790 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。