L-Arginine HCl (L-Arg)

製品コードS3174 バッチS317401

印刷

化学情報

Chemical Structure Synonyms (S)-(+)-Arginine hydrochloride Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C6H14N4O2.HCl
分子量 210.66 CAS No. 1119-34-2
Solubility (25°C)* 体外 Water 42 mg/mL (199.37 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 L-Arginine(L-arg,(S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.L-Arginine HCl (L-Arg) can be used to induce animal models of Acute Pancreatitis.
in vitro

L-Arginine HCl (L-Arg) (0.3 mM, 30 minutes) supplementation does not induce any significant increases in the peak NO concentration at low level of native LDL. However, at native LDL concentrations from 60-130 mg cholesterol/dL, NO concentration is 2 times higher than before this compound treatment in bovine aortic endothelial cells. Its pretreatment results in a significant increase of NO production in n-LDL–treated cells as well as in oxidized -LDL–treated cells in bovine aortic endothelial cells. It does not increase O2- concentration at low nativeLDL concentrations but reduce O2- production by 50% when incubate with n-LDL at concentrations >40 mg cholesterol/dL in bovine aortic endothelial cells. This compound pretreatment completely abolishes O2- production at every oxidized LDL dosage in bovine aortic endothelial cells. [1]
in vivo

L-Arginine HCl (L-Arg) (4 mg/kg/min for 1 hour) treatment decreases superoxide generation by cNOS while increasing NO accumulation in rabbit limb during ischemia/reperfusion. It prevents microvessel constriction in the reperfused muscle despite reduced but still apparent interstitial edema in rabbit limb. This compound results in a significant reduction of muscular reperfusion edema in rabbit limb. [2] Its supplementation (0.1 g/kg, oral) significantly reduces pulmonary artery systolic pressure by a mean of 15.2% after 5 days of therapy in patients with sickle cell disease. Both L-Arginine and ornithine concentrations increased significantly after 5 days of oral supplementation with it (0.1 g/kg) in patients with sickle cell disease. [3] It is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. [4] This compound (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice. [5]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/10725285/
  • https://pubmed.ncbi.nlm.nih.gov/9244241/
  • https://pubmed.ncbi.nlm.nih.gov/12626350/
  • https://pubmed.ncbi.nlm.nih.gov/14707554/
  • https://pubmed.ncbi.nlm.nih.gov/10779015/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [ J Immunother Cancer, 2024, 12(11)e009805] PubMed: 39581704
P4HA1 as an unfavorable prognostic marker promotes cell migration and invasion of glioblastoma via inducing EMT process under hypoxia microenvironment [ Am J Cancer Res, 2021, 11(2):590-617] PubMed: 33575089
S100A9 gene silencing inhibits the release of pro‐inflammatory cytokines by blocking the IL‐17 signalling pathway in mice with acute pancreatitis [Dong‐Mei Wu, et al. J Cell Mol Med, 2018, 10.1111/jcmm.13532]
S100A9 gene silencing inhibits the release of pro-inflammatory cytokines by blocking the IL-17 signalling pathway in mice with acute pancreatitis. [ J Cell Mol Med, 2018, 22(4):2378-2389] PubMed: 29441717

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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