L-Citrulline

製品コードS3798 バッチS379801

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₆H₁₃N₃O₃
	分子量	175.19	CAS No.	372-75-8
Solubility (25°C)*	体外	Water	35 mg/mL (199.78 mM)
		DMSO	Insoluble

* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	L-citrulline is a substance called a non-essential amino acid that is used as a sports performance and cardiovascular health supplement.
in vitro	L-Citrulline restores nitric oxide/reactive oxygen species balance and barrier function in high glucose-treated monolayers of human glomerular endothelial cells. Moreover, this compound also has the ability to establish an anti-inflammatory profile, characterized by increased IL-10 and reduced IL-1β and IL-12(p70) generation in the human proximal tubular cells^[1].
in vivo	Oral l-cit (precursor of l-arg) augments NO-dependent signaling, not only by means of increasing l-arg synthesis, but also by decreasing l-arg catabolism, as such increasing circulating l-arg levels. This compound exerts protective effects in kidneys of STZ-rats, and markedly reduces urinary albumin excretion, tubulo-interstitial fibrosis, and kidney hypertrophy, observed in untreated diabetic mice^[1]. Its supplementation also strengthens vascular endothelium function and attenuates stress-induced cold hypersensitivity by improving blood circulation^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Human glomerular endothelial cells
	濃度	1 mM
	反応時間	2 h
	実験の流れ	Human glomerular endothelial cell are seeded at 1 × 10⁵ cells per well in 24-well plates. Confluent quiescent cell monolayers are exposed to HG or proper iso-osmotic control for 24 h. L-Citrulline (1 mM) is applied 2 h prior to HG. Exposure is terminated by removal of the supernatant. Fresh basic CSC medium is replaced and cells incubated for additional 30 min. Supernatant is then removed, subsequently centrifuged and stored at −80°C for NO analysis.
動物実験	動物モデル	diabetic mice (C57BL/6 mice, intraperitoneal injections of STZ)
	投薬量	50 mg/kg
	投与方法	oral

参考

https://pubmed.ncbi.nlm.nih.gov/24400007/
https://pubmed.ncbi.nlm.nih.gov/25276066/

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。