L-SelenoMethionine

製品コードS3973 バッチS397301

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C5H11NO2Se
分子量 196.11 CAS No. 3211-76-5
Solubility (25°C)* 体外 Water 39 mg/mL (198.86 mM)
DMSO Insoluble
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.
in vitro L-SelenoMethionine (SeMet) has also been shown to contribute to the mitigation of radiation-induced oxidative stress. This compound has the ability to selectively induce apoptosis and growth arrest in cancerous, but not normal, human prostate cells. Mechanistically, its treatment is shown to promote growth inhibition in human colon cancer cells through the phosphorylation of histone H3 via the activation of MAPK extracellular regulated kinase (ERK) and subsequent phosphorylation of the ribosomal S6 kinase (RSK)[1].
in vivo L-SelenoMethionine (SeMet) increases survival time of NK/Ly lymphoma bearing animals treated with doxorubicin. This compound can effectively protect the hematopoietic system and liver of tumor-bearing animals with NK/Ly lymphoma from the side effects of anticancer drug doxorubicin, which is revealed by normalization of blood indexes, animal weight, and ALT/AST activity[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Human thyroid epithelial cells (HTori-3)
濃度 5 μM
反応時間 24 h
実験の流れ Human thyroid epithelial cells (HTori-3) are maintained in Dulbecco's modified Eagle's medium (DMEM)/F12 supplemented with 1% glutamine and 10% FBS (growth medium). Twenty-four hours prior to irradiation with iron ions, fresh medium with or without 5 μM of this compound is added. At the time of radiation exposure, the cells are approximately 80% confluent.
動物実験 動物モデル NL/Ly lymphoma-bearing mice
投薬量 60 μg/kg, cumulative dose 600 μg/kg
投与方法 p.o.

参考

  • https://pubmed.ncbi.nlm.nih.gov/23946774/
  • https://pubmed.ncbi.nlm.nih.gov/27106359/

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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