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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C49H54F2N8O6 |
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分子量 | 889.0 | CAS No. | 1256388-51-8 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (112.48 mM) | |
Ethanol | 100 mg/mL (112.48 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Ledipasvir (GS5885) is a HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection. |
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Data from [Data independently produced by , , Sci Rep, 2017, 7(1):9223]
Characterization of fluorescent probe substrates to develop an efficient high-throughput assay for neonatal hepatic CYP3A7 inhibition screening [ Sci Rep, 2021, 11(1):19443] | PubMed: 34593846 |
Hepatic Stress Response in HCV Infection Promotes STAT3-Mediated Inhibition of HNF4A-miR-122 Feedback Loop in Liver Fibrosis and Cancer Progression [ Cancers (Basel), 2019, 11(10)E1407] | PubMed: 31547152 |
Estimating efflux transporter-mediated disposition of molecules beyond the rule of five (bRo5) using transporter gene knockout rats. [ Biol Pharm Bull, 2019, 10.1248/bpb.b19-00641] | PubMed: 31685755 |
HA1077 displays synergistic activity with daclatasvir against hepatitis C virus and suppresses the emergence of NS5A resistance-associated substitutions in mice. [ Sci Rep, 2018, 8(1):12469] | PubMed: 30127498 |
Oligonucleotide-Lipid Conjugates Forming G-Quadruplex Structures Are Potent and Pangenotypic Hepatitis C Virus Entry Inhibitors In Vitro and Ex Vivo [ Antimicrob Agents Chemother, 2017, 61(5)e02354-16] | PubMed: 28193659 |
Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture. [Aydin Y, et al. Sci Rep, 2017, 7(1):9223] | PubMed: 28835697 |
Manipulation of both virus- and cell-specific factors is required for robust transient replication of a hepatitis C virus genotype 3a sub-genomic replicon. [ J Gen Virol, 2017, 98(10):2495-2506] | PubMed: 28984238 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。