Leonurine

製品コードS3890 バッチS389001

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₄H₂₁N₃O₅
	分子量	311.33	CAS No.	24697-74-3
Solubility (25°C)*	体外	DMSO	Insoluble


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Leonurine, an active alkaloid extracted from Traditional Chinese Medicine Herba leonuri, exerts several biological effects, such as antidiabetic, cardiovascular, and bovine mastitis protection.
in vitro	Leonurine inhibits U937 cells adhesion to TNF-α-activated HUVEC in a concentration dependent manner. Treatment with this compound blocks TNF-α-induced mRNA and protein expression of adhesion molecules (intercellular adhesion molecule-1 and vascular cell adhesion molecule-1), cyclooxygenase-2, and monocyte chemoattractant protein-1 in endothelial cells. In addition, this compound attenuates TNF-α-induced intracellular ROS production in HUVEC. Furthermore, it suppresses the TNF-α-activated p38 phosphorylation and IκBα degradation. Subsequently reduced NF-κB p65 phosphorylation, nuclear translocation, and DNA-binding activity are also observed^[1]. This chemical attenuates DOX-induced apoptosis in H9c2 cell by increasing anti-oxidant, anti-apoptotic ability and protecting mitochondrial function^[4].
in vivo	Leonurine attenuates hyperalgesia in mice with induced adenomyosis via down-regulating expressions of p-P65, COX-2, and OTR, and could be beneficial for treating adenomyosis^[2]. This compound exerts antidepressant-like effects, which may be mediated, at least in part, by improving monoamine neurotransmitters and inhibiting neuroinflammation. It possesses neuroprotective effects in animal models of ischemic stroke, parkinson's disease, and alzheimer's disease. This chemical treatment significantly rescues behavioral deficit of animals, promotes neuronal survival, and inhibits inflammation^[3].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Rat embryonic ventricularmyocardial H9c2 cell line
	濃度	10 μM
	反応時間	2 h
	実験の流れ	Cells are using for Hoechst staining after treatement. DOX treatment: cells are exposed to 1 μM DOX for 24 h; Leo treatment: cells are pre-treated with 10 μM this compound for 2 h before exposure to DOX.
動物実験	動物モデル	Male C57BL/6 (8–10 weeks) mice
	投薬量	30 and 60 mg/kg
	投与方法	intragastric administration

参考

https://pubmed.ncbi.nlm.nih.gov/22326051/
https://pubmed.ncbi.nlm.nih.gov/28389633/
https://pubmed.ncbi.nlm.nih.gov/29016795/

https://pubmed.ncbi.nlm.nih.gov/19356731/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Novel insights into the protective effects of leonurine against acute kidney injury: Inhibition of ER stress-associated ferroptosis via regulating ATF4/CHOP/ACSL4 pathway [ Chem Biol Interact, 2024, 395:111016]	PubMed: 38670420

Novel insights into the protective effects of leonurine against acute kidney injury: Inhibition of ER stress-associated ferroptosis via regulating ATF4/CHOP/ACSL4 pathway [ Chem Biol Interact, 2024, 395:111016]

PubMed: 38670420

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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