Licochalcone A

製品コードS7828 バッチS782801

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₁H₂₂O₄

分子量

338.4

CAS No.

58749-22-7

Solubility (25°C)*

体外

DMSO

67 mg/mL (197.99 mM)

Ethanol

67 mg/mL (197.99 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	3.35mg/ml (9.90mM)	Taking the 1 mL working solution as an example, add 50 μL of 67 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.47mg/ml (1.39mM)	Taking the 1 mL working solution as an example, add 50 μL of 9.4 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Licochalcone Aは、カンゾウ根から抽出されたエストロゲンフラボノイドで、抗マラリア作用、抗癌作用、抗菌作用、抗ウイルス作用を示します。フェーズ3。
in vitro	Licochalcone A markedly inhibits the in vitro growth of L. major amastigotes in human MDMs and U937 cells. This compound shows antibacterial effects against all gram-positive bacteria tested and especially against all Bacillus spp. Tested with MICs of 2 to 3 micrograms/mL. In CT-26 colon cancer cells, it reduces the cell viability and DNA synthesis. It also interferes with MAPK signaling cascades, initiates ROS generation, induces oxidative stress and consequently causes BGC cell apoptosis.
in vivo	In mice infected with L. major, licochalcone A (5 mg/kg, i.p.) completely prevents lesion development. In mice infected with L. donovani, this compound (150 mg/kg, p.o.) results in > 65 and 85% reductions of parasite loads in the liver and the spleen, respectively. In CT-26 cell-inoculated Balb/c mice, this chemical (1 mg/kg, p.o.) inhibits the tumor growth, and alleviates cisplatin-induced nephrotoxicity and hepatotoxicity.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	CT-26 cells
	濃度	~20 μM
	反応時間	72 hours
	実験の流れ	The viability of CT-26 mouse colon cancer cells is determined via a MTT assay. In brief, colon cancer cells are seeded onto each well of a 96-well plate with DMEM containing 10% FBS and cultured to adhere overnight. The cells are then treated with various concentrations of this compound in serum-free medium for 24 and 72 hr, respectively. Twenty microlitres of a MTT solution (5 mg/ml) is added to each well, and the cells are incubated for 4 hr at 37°. The medium is then removed, and 200 µL of dimethyl sulfoxide is added to each well. The absorbance is determined at 570 nm using a microplate reader.
動物実験	動物モデル	Mice infected with L. major
	投薬量	5 mg/kg/day
	投与方法	i.p. or p.o.

参考

https://pubmed.ncbi.nlm.nih.gov/8109916/
https://pubmed.ncbi.nlm.nih.gov/8092835/
https://pubmed.ncbi.nlm.nih.gov/11959549/

https://pubmed.ncbi.nlm.nih.gov/18484961/
https://pubmed.ncbi.nlm.nih.gov/25981581/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Licochalcone A protects against LPS-induced inflammation and acute lung injury by directly binding with myeloid differentiation factor 2 (MD2) [ Br J Pharmacol, 2023, 180(8):1114-1131]	PubMed: 36480410
Licochalcone a improves cardiac functions after ischemia-reperfusion via reduction of ferroptosis in rats [ Eur J Pharmacol, 2023, 957:176031]	PubMed: 37660967
JNK inhibitor IX restrains pancreatic cancer through p53 and p21 [ Front Oncol, 2022, 12:1006131]	PubMed: 36568248
Licochalcone A Promotes the Ubiquitination of c-Met to Abrogate Gefitinib Resistance [ Biomed Res Int, 2022, 2022:5687832]	PubMed: 35309168
Licochalcone A inhibits cell growth through the downregulation of the Hippo pathway via PES1 in cholangiocarcinoma cells [ Environ Toxicol, 2021, 10.1002/tox.23422]	PubMed: 34845814

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。