Linalool

製品コードS4957 バッチS495701

印刷

化学情報

Chemical Structure Synonyms Phantol Storage
(From the date of receipt)		 2 years -80°C liquid
化学式

C10H18O
分子量 154.25 CAS No. 78-70-6
Solubility (25°C)* 体外  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

生物活性

製品説明 Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.
in vitro Linalool exhibits a good cytotoxic effect on U937 and HeLa cells, with the IC50 value of 2.59 and 11.02 μM, respectively. Linalool inhibits the growth of various human cancer cells by causing apoptotic cell death. It can induce the cell cycle of U937 cells to arrest at the G0/G1 phase, while HeLa cells arrest at the G2/M phase, and its function facilitates the expression of p53, p21, p27, p16, and p18 (CDKIs) and the non-expression of CDK activity[3]. Linalool non-selectively suppresses the voltage-gated currents in newt sensory neurons and rat cerebellar Purkinje cells[4].
in vivo Linalool (i.p. 10-200mg/kg; p.o., 5-100mg/kg) shows significant antinociceptive activity against glutamate induced pain in mice, possible due mechanisms operated by ionotropic glutamate receptors, namely AMPA, NMDA and kainate but not via metabotropic receptors. Linalool (50-150mg/kg, s.c.) shows antinociceptive activity in formalin and hot-plate tests. This effect is mediated by NMDA, opioid dopamine D2, muscarinic M2 receptors and KATP channels. Linalool (50 and 100mg/kg doses) impairs long-term memory acquisition, but not short-term memory acquisition, in the object recognition task in rats[1].
密度 0.87 g/mL at 25 °C

プロトコル(参考用のみ)

細胞アッセイ 細胞株 U937 cells
濃度 1.30, 1.94, 3.24, and 6.48 μM
反応時間 24 h
実験の流れ

Water-soluble tetrazolium salts (WST-1) analysis is used to determine inhibition of cell growth by varying the concentrations (1.30, 1.94, 3.24, and 6.48 μM) of linalool administered to U937 cells (1.2 × 105/mL) and activating for 24 h.
動物実験 動物モデル Adult male albino mice
投薬量 50, 75 and 100 mg/kg
投与方法 i.p.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。