Liproxstatin-1

製品コードS7699 バッチS769907

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₉H₂₁ClN₄
	分子量	340.85	CAS No.	950455-15-9
Solubility (25°C)*	体外	DMSO	68 mg/mL (199.5 mM)
		Ethanol	5 mg/mL warmed with 50ºC water bath (14.66 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.
in vitro	Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4^−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4^−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H₂O₂ (200 µM).^[1]
in vivo	Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury. ^[1]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Gpx4^−/−cells
	濃度	~200 nM
	反応時間	~72 h
	実験の流れ	Cell viability is assessed at different time points after treatment using AquaBluer according to the manufacturer’s recommendations. Alternatively, cell death is also quantified by measuring released lactate dehydrogenase activity using the cytotoxicity detection kit (LDH).
動物実験	動物モデル	GreER^T2; Gpx4^fI/fI mice
	投薬量	10 mg/kg
	投与方法	i.p.

参考

[1] Friedmann Angeli JP, et al. Nat Cell Biol. 2014, 16(12):1180-1191.

カスタマーフィードバック

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: Data from [Data independently produced by , , Mol Psychiatry, 2017, 22(11):1520-1530]

: Data from [Data independently produced by , , Cancer Res, 2017, 77(8):2064-2077]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

7-Dehydrocholesterol dictates ferroptosis sensitivity [ Nature, 2024, 626(7998):411-418.]	PubMed: 38297130
Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence [ Nat Commun, 2024, 15(1):1429]	PubMed: 38365899
The SOX4/EZH2/SLC7A11 signaling axis mediates ferroptosis in calcium oxalate crystal deposition-induced kidney injury [ J Transl Med, 2024, 22(1):9]	PubMed: 38169402
PKCiota Inhibits the Ferroptosis of Esophageal Cancer Cells via Suppressing USP14-Mediated Autophagic Degradation of GPX4 [ Antioxidants (Basel), 2024, 13(1)114]	PubMed: 38247539
Ferroptosis contributes to JEV-induced neuronal damage and neuroinflammation [ Virol Sin, 2024, 39(1):144-155]	PubMed: 38104890
Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells [ J Virol, 2024, 98(3):e0189723]	PubMed: 38411946
Inhibition of ferroptosis by POLE2 in gastric cancer cells involves the activation of NRF2/GPX4 pathway [ J Cell Mol Med, 2024, 28(1):e17983]	PubMed: 38070189
The cell fate regulator DACH1 modulates ferroptosis through affecting P53/SLC25A37 signaling in fibrotic disease [ Hepatol Commun, 2024, 8(3)e0396]	PubMed: 38437058
Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo [ Sci Adv, 2024, 10(7):eadk1835]	PubMed: 38354236
A tangible method to assess native ferroptosis suppressor activity [ Cell Rep Methods, 2024, S2667-2375(24)00025-0]	PubMed: 38401540

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。