Liproxstatin-1

製品コードS7699 バッチS769907

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₉H₂₁ClN₄

分子量

340.85

CAS No.

950455-15-9

Solubility (25°C)*

体外

DMSO

68 mg/mL (199.5 mM)

Ethanol (warmed with 50ºC water bath)

5 mg/mL (14.66 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Liproxstatin-1は、IC50が22 nMの強力な強誘電性阻害剤です。
in vitro	Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4^−/−cells with IC50 of 22 nM. This compound (50 nM) completely prevents lipid peroxidation in Gpx4^−/−cells. It (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H₂O₂ (200 µM).
in vivo	Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Gpx4^−/−cells
	濃度	~200 nM
	反応時間	~72 h
	実験の流れ	Cell viability is assessed at different time points after treatment using AquaBluer according to the manufacturer’s recommendations. Alternatively, cell death is also quantified by measuring released lactate dehydrogenase activity using the cytotoxicity detection kit (LDH).
動物実験	動物モデル	GreER^T2; Gpx4^fI/fI mice
	投薬量	10 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/25402683/

カスタマーフィードバック

: ,

: Data from [Data independently produced by , , Mol Psychiatry, 2017, 22(11):1520-1530]

: Data from [Data independently produced by , , Cancer Res, 2017, 77(8):2064-2077]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

FAAH initiates a positive feedback loop to promote lung adenocarcinoma progression through inhibition of ferroptosis [ Cell Death Differ, 2026, 10.1038/s41418-026-01742-5 10.1038/s41571-023-00798-3 10.1158/0008-5472.CAN-24-1607 10.1126/scitranslmed.abk2756 10.1038/s41580-024-00703-5 10.1038/s4]	PubMed: 41998116
Ipriflavone From Aquilaria malaccensis Lam. Exosome-Like Nanoparticles Targets Prolyl Hydroxylase Domain Protein 2 (PHD2) to Enhance Hypoxia-Inducible Factor-α (HIF-α) Hydroxylation Thereby Alleviating Hypoxia-Induced Gastrointestinal Mucosal Ferroptosis [ MedComm (2020), 2026, 7(4):e70722]	PubMed: 41969632
Opposing roles of DGAT-mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity [ FEBS J, 2026, 10.1111/febs.70467]	PubMed: 41729026
Nrf2 de-SUMOylation alleviates myocardial ischemia-reperfusion injury (MIRI) by attenuating myocardial ferroptosis in mice [ Redox Rep, 2026, 31(1):2624946]	PubMed: 41645807
Cytosolic cytochrome c represses ferroptosis [ Cell Metab, 2025, S1550-4131(25)00149-4]	PubMed: 40233758
Endothelial but not systemic ferroptosis inhibition protects from antineutrophil cytoplasmic antibody-induced crescentic glomerulonephritis [ Kidney Int, 2025, 107(6):1037-1050]	PubMed: 40122342
S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism [ Nat Commun, 2025, 16(1):509]	PubMed: 39779666
Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma [ Cancer Commun (Lond), 2025, 10.1002/cac2.70036]	PubMed: 40443016
A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation [ Neuron, 2025, S0896-6273(25)00136-9]	PubMed: 40101721
HIF-independent oxygen sensing via KDM6A regulates ferroptosis [ Mol Cell, 2025, 85(15):2973-2987.e6]	PubMed: 40712585

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。