Liquiritigenin

製品コードS3929 バッチS392901

印刷

化学情報

Synonyms

4',7-Dihydroxyflavanone

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₅H₁₂O₄

分子量

256.25

CAS No.

578-86-9

Solubility (25°C)*

体外

DMSO

51 mg/mL (199.02 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Liquiritigenin (4',7-Dihydroxyflavanone) は、カンゾウ（Glycyrrhizae uralensis Fisch）の根から得られる最も活性の高いエストロゲン化合物で、ERβに選択的に結合し（IC50値 7.5 μM）、複数のER調節エレメントおよびネイティブターゲット遺伝子をErβを介して活性化しますが、ERαを介しては活性化しません。
in vitro	Liquiritigenin-treated murine osteoblastic MC3T3-E1 cells shows an increased alkaline phosphatase activity and enhances phosphorylation of Smad1/5 compared with untreated cells. Moreover, this compound inhibits osteoclast differentiation, its bone-resorption activity through slightly decreases the phosphorylation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and inhibitor of nuclear factor kappa B-α ; however, the phosphorylation of Akt and p38 slightly increase in bone marrow-derived osteoclasts. The expression levels of the osteoclast marker proteins nuclear factor of activated T-cell cytoplasmic-1, Src, and cathepsin K diminish. This chemical is shown to exert the following pharmacological effects: increased cell growth, increased alkaline phosphatase activity, promotion of collagen synthesis, and the mineralization of osteoblastic MC3T3-E1 cells. It inhibits serum-induced HIF-1α and VEGF expression via the AKT/mTOR-p70S6K signaling pathway in HeLa cells.
in vivo	Liquiritigenin inhibits the growth of tumors in nude mice originating from human cervical cancer cell line HeLa cells, and reduces angiogenesis in a dose dependent manner. This compound effectively reduces the levels of pro-inflammatory cytokines and the expressions of p-p65NF-κB and p-IκBα. Furthermore, its preconditioning could down-regulate the immobility time in tail suspension test (TST), forced swimming test (FST) and up-regulate BDNF and TrkB contents in hippocampus. Thus, this chemical has antidepressant activity that might be attributed to its anti-inflammatory property and BDNF/TrkB signaling pathway.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Murine osteoblastic MC3T3-E1 cells
	濃度	0-100 μM
	反応時間	72 h
	実験の流れ	Cells seeded in 96-well cell culture plates are incubated with the Cell Counting Kit-8 for 1 h, and then the absorbance at 450nm is measured with a microplate reader.
動物実験	動物モデル	nude BALB/c mice.
	投薬量	10, 20, 40 mg/kg
	投与方法	intragastrically

参考

https://pubmed.ncbi.nlm.nih.gov/26172226/
https://pubmed.ncbi.nlm.nih.gov/18177995/
https://pubmed.ncbi.nlm.nih.gov/22692244/

https://pubmed.ncbi.nlm.nih.gov/27107388/

+ 展开

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

The SIRT1/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin [ Chin Med, 2024, 19(1):12]	PubMed: 38238857
Liquiritigenin attenuates isoprenaline‑induced myocardial fibrosis in mice through the TGF‑β1/Smad2 and AKT/ERK signaling pathways [ Mol Med Rep, 2021, 24(4)686]	PubMed: 34328199

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。