Liraglutide

製品コードS8256 バッチS825603

化学情報

	Synonyms	NN2211, Liraglutida, Liraglutidum	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₇₂H₂₆₅N₄₃O₅₁
	分子量	3751.25	CAS No.	204656-20-2
Solubility (25°C)*	体外	0.5MNAOH	10.07 mg/mL (2.68 mM)
		Water	Insoluble

* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Liraglutide is a long-acting glucagon-like peptide-1(GLP-1) receptor agonist.
in vitro	Liraglutide attenuates induction of plasminogen activator inhibitor type-1 (PAI-1) and vascular adhesion molecule (VAM) expression in human vascular endothelial cells (hVECs) in vitro and may afford protection against endothelial cell dysfunction (ECD), an early abnormality in diabetic vascular disease. In vitro studies demonstrates GLP-1R-dependent liraglutide-mediated inhibition of stimulated PAI-1 and VAM expression^[3].
in vivo	In vivo studies of vascular reactivity and immunohistochemical analysis are performed in the ApoE-/- mouse model. They demonstrate significant improvement in endothelial function in liraglutide treated mice, a GLP-1R dependent effect. Liraglutide treatment also increases endothelial nitric oxide synthase (eNOS) and reduces intercellular adhesion molecule-1 (ICAM-1) expression in aortic endothelium, an effect again dependent on the GLP-1R^[3]. Liraglutide reduces hyperglycemia in T2D mouse models by increasing pancreatic b cell mass through enhanced proliferation^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	human umbilical vein endothelial cell line C11-STH20
	濃度	100 nM
	反応時間	16 h
	実験の流れ	C11-STH cells are cultured to confluence at 37°C in gelatin-coated Nunclon cell culture dishes in Media-199 supplemented with penicillin/streptomycin, 20% FCS, 20 µg/ml endothelial cell growth factor and 20 µg/ml heparin. C11-STH cells are incubated under serum free conditions with liraglutide (100 nM) or the GLP-1 receptor antagonist exendin (9-39) (100 nM) alone or with 10 ng/ml TNFα for 16 h alone or in combination with liraglutide and/or exendin (9-39). ELISA assays for VCAM-1 and ICAM-1 are performed using conditioned medium from C11-STH cells to determine protein expression levels.
動物実験	動物モデル	Athymic nude mice
	投薬量	300 μg/kg/day
	投与方法	s.c.

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy [ J Immunother Cancer, 2024, 12(3)e008431]	PubMed: 38458640
Targeting Clic1 for the treatment of obesity: A novel therapeutic strategy to reduce food intake and body weight [ Mol Metab, 2023, 76:101794]	PubMed: 37604246
Targeting Clic1 for the treatment of obesity: A novel therapeutic strategy to reduce food intake and body weight [ Mol Metab, 2023, 76:101794]	PubMed: 37604246
A versatile pumpless multi-channel fluidics system for maintenance and real-time functional assessment of tissue and cells [ Cell Rep Methods, 2023, 3(11):100642]	PubMed: 37963464
Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety [ bioRxiv, 2023, 10.1101/2023.10.31.564990]	PubMed: 37961449
Dietary resistant starch ameliorating lipopolysaccharide-induced inflammation in meat ducks associated with the alteration in gut microbiome and glucagon-like peptide 1 signaling [ J Anim Sci Biotechnol, 2022, 13(1):91]	PubMed: 35836245
Liraglutide, a glucagon-like peptide-1 receptor agonist, induces ADAM10-dependent ectodomain shedding of RAGE via AMPK activation in human aortic endothelial cells [ Life Sci, 2022, 292:120331]	PubMed: 35041837
Improved Split TEV GPCR β-arrestin-2 Recruitment Assays via Systematic Analysis of Signal Peptide and β-arrestin Binding Motif Variants [ Biosensors (Basel), 2022, 13(1)48]	PubMed: 36671883
Liraglutide Alleviates Diabetic Atherosclerosis through Regulating Calcification of Vascular Smooth Muscle Cells [ Dis Markers, 2022, 2022:5013622]	PubMed: 35510038
14-3-3-zeta mediates GLP-1 receptor agonist action to alter α cell proglucagon processing [ Sci Adv, 2022, 8(29):eabn3773]	PubMed: 35867787

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。