LM11A-31

製品コードS9848 バッチS984801

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₁₂H₂₅N₃O₂

分子量

243.35

CAS No.

289475-77-0

Solubility (25°C)*

体外

DMSO

49 mg/mL (201.35 mM)

Water

49 mg/mL (201.35 mM)

Ethanol

49 mg/mL (201.35 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	2.45mg/ml (10.07mM)	Taking the 1 mL working solution as an example, add 50 μL of 49 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.35mg/ml (1.44mM)	Taking the 1 mL working solution as an example, add 50 μL of 7 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	LM11A-31 is a small molecule p75^NTR Ligand that reverses cholinergic neurite dystrophy in alzheimer's diseasemousemodels with mid- to late-stage disease progression.
in vitro	LM11A-31 greatly reduces or eliminates the neuronal pathology as well as the FIV effects on astrocytes and microglia in an infectious in vitro model, indicating an excellent potential for the treatment of HIV-associated neurodegeneration.<sup><a class="sref" href="#s_ref">[1]</a></sup>
in vivo	LM11A-31 is a small molecular p75^NTR ligand, which reverses cholinergic neurite dystrophy in mice with advanced Alzheimer's disease.^[2]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Feline choroid plexus macrophages infected with FIV
	濃度	10 nM
	反応時間	14 h
	実験の流れ	Cat neurons were seeded at a very low density and half the cultures were treated with 10 nM LM11A-31 in the medium. Initial seeding density was matched within each run at approximately 2,800-4,000 cells/cm2 and cultures were fed every 2 days with complete MEM or MEM + this compound.
動物実験	動物モデル	Thy-1 hAPP^Lond/Swe (APP^L/S) and Tg2576 mouse model
	投薬量	50 mg/kg for APP^L/S mouse; 10, 50, 75 and 100 mg/kg/day (n=3-4 Tg2576 mice/dose)
	投与方法	Oral gavage

参考

https://pubmed.ncbi.nlm.nih.gov/22161560/
https://pubmed.ncbi.nlm.nih.gov/25153701/

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。