LY2090314

製品コードS7063 バッチS706304

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₈H₂₅FN₆O₃
	分子量	512.53	CAS No.	603288-22-8
Solubility (25°C)*	体外	DMSO	50 mg/mL (97.55 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases.
in vitro	LY2090314 selectively inhibits the activity of GSK-3 by interrupting ATP binding. LY2090314 is able to stabilize β-catenin. LY2090314 shows limited efficacy as monotherapy. LY3090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer cell lines in vitro. ^[1]
in vivo	LY2090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer xenografts. ^[1]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	A375 cells
	濃度	20 nM
	反応時間	5 h
	実験の流れ	Cells were treated with various concentrations of drug for 5 h.
動物実験	動物モデル	Female athymic nude mice
	投薬量	25 mg/kg
	投与方法	i.v

参考

カスタマーフィードバック

: Data from [Data independently produced by , , Cancer Res, 2017, 77(21):5873-5885]

: Data from [Data independently produced by , , Mol Cancer Ther, 2016, 15(7):1485-94.]

: Data from [Data independently produced by , , Stem Cell Res, 2017, 182-187]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Integrin-mediated electric axon guidance underlying optic nerve formation in the embryonic chick retina [ Commun Biol, 2023, 6(1):680]	PubMed: 37391492
Integrin-mediated electric axon guidance underlying optic nerve formation in the embryonic chick retina [ Commun Biol, 2023, 6(1):680]	PubMed: 37391492
Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis [ Cell, 2021, 184(1):243-256.e18]	PubMed: 33417861
ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation [ Nat Commun, 2021, 12(1):2346]	PubMed: 33879767
KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis [ Mol Cell, 2021, S1097-2765(21)00735-8]	PubMed: 34551282
GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis [ Cell Death Discov, 2021, 7(1):334]	PubMed: 34732689
A GSK3-SRF Axis Mediates Angiotensin II Induced Endothelin Transcription in Vascular Endothelial Cells [ Front Cell Dev Biol, 2021, 9:698254]	PubMed: 34381779
Glycogen synthase kinase-3 beta (GSK3β)-mediated phosphorylation of ETS1 promotes progression of ovarian carcinoma [ Aging (Albany NY), 2021, 13(10):13739-13763]	PubMed: 34023818
C81-evoked inhibition of the TNFR1-NFκB pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes [ FASEB J, 2021, 35(6):e21656]	PubMed: 34042211
CMTM8 as an LPA1-associated partner mediates lysophosphatidic acid-induced pancreatic cancer metastasis [ Ann Transl Med, 2021, 9(1):42]	PubMed: 33553335

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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