LY2409881

製品コードS7697 バッチS769701

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C24H32Cl4N6OS
分子量 594.43 CAS No. 946518-60-1
Solubility (25°C)* 体外 DMSO 100 mg/mL warmed with 50ºC water bath (168.22 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.
in vitro LY2409881 inhibits constitutively activated NF-ƘB, and causes concentration- and time-dependent growth inhibition and apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. In the ovarian cancer cell line SKOV3, LY2409881 demonstrates moderate cytotoxicity. LY2409881 is synergistic with doxorubicin and cyclophosphamide in SUDHL2 cell in inhibiting the cell growth, but not in LY1 cell. In both SUDHL2 and LY1 cells, LY2409881 is synergistic with the histone deacetylase (HDAC) inhibitor romidepsin in inhibiting the cell growth.[1]
in vivo In SCID-beige xenograft mouse model, LY2409881 (50, 100, and 200 mg/kg, i.p.) significantly inhibits the tumor growth.[1]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 OCI-LY10 cells
濃度 25 μM
反応時間 ~72 h
実験の流れ Cytotoxicity is evaluated using the CellTiter-Glo Reagent according to the manufacturer's manual. Experiments are carried out in 96-well plates, with each treatment in triplicate. Samples are taken at typically 24, 48, and 72 hours after treatment. Cytotoxicity is expressed by the decreasing percentage of live cells in each treatment relative to the untreated control from the same experiment. IC50 for each cell line is calculated using the CalcuSyn Version 2.0 software.
動物実験 動物モデル SCID-beige xenograft mouse model
投薬量 100 mg/kg
投与方法 i.p.

カスタマーフィードバック

Data from [Data independently produced by , , Biochem Biophys Res Commun, 2018, 503(1):94-101]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions. [ Nat Commun, 2019, 10(1):2924] PubMed: 31266950
PET Imaging of VCAM-1 Expression and Monitoring Therapy Response in Tumor with a 68Ga-Labeled Single Chain Variable Fragment. [ Mol Pharm, 2018, 15(2):609-618] PubMed: 29308904
Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1 [ J Biol Chem, 2018, 293(30):11913-11927] PubMed: 29899110
Angptl2 deficiency attenuates paraquat (PQ)-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis through NF-κB pathway [Yang W, et al. Biochem Biophys Res Commun, 2018, 503(1):94-101] PubMed: 29852175
Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. [Tse AK, et al. Redox Biol, 2017, 11:562-576] PubMed: 28107677

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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