LY2584702 Tosylate

製品コードS7704 バッチS770402

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C28H27F4N7O3S
分子量 617.62 CAS No. 1082949-68-5
Solubility (25°C)* 体外 DMSO (warmed with 50ºC water bath) 100 mg/mL (161.91 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.
in vitro In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. [1] LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus. [2]
in vivo LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. [1]

プロトコル(参考用のみ)

動物実験 動物モデル U87MG glioblastoma and HCT116 colon carcinoma xenograft models
投薬量 12.5 mg/kg BID
投与方法 --

参考

  • https://pubmed.ncbi.nlm.nih.gov/24440085/
  • https://pubmed.ncbi.nlm.nih.gov/24456794/

カスタマーフィードバック

Data from [Data independently produced by , , PLoS One, 2017, 12(1):e0169804]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Deep PIM kinase substrate profiling reveals new rational cotherapeutic strategies for acute myeloid leukemia [ Blood Adv, 2024, 8(15):3880-3892] PubMed: 38739710
Nutrient-regulated control of lysosome function by signaling lipid conversion [ Cell, 2023, 186(24):5328-5346.e26] PubMed: 37883971
Nutrient-regulated control of lysosome function by signaling lipid conversion [ Cell, 2023, 10.1016/j.cell.2023.09.027] PubMed: 37883971
Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly [ Nat Commun, 2022, 13(1):4848] PubMed: 35977928
Sustained oncogenic signaling in the cytostatic state enables targeting of non-proliferating persistent cancer cells [ Cancer Res, 2022, can.21.2908] PubMed: 35792658
P311 Facilitates the Angiogenesis and Wound Healing Function of MSCs by Increasing VEGF Production [ Front Immunol, 2022, 13:821932] PubMed: 35154140
Differential expression of gene co-expression networks related to the mTOR signaling pathway in bipolar disorder [ Transl Psychiatry, 2022, 12(1):184] PubMed: 35508467
B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells [ Cell Signal, 2022, 94:110311] PubMed: 35306137
Inhibition of RPS6K reveals context-dependent Akt activity in luminal breast cancer cells [ PLoS Comput Biol, 2021, 17(6):e1009125] PubMed: 34191793
Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRASMUT melanoma [ bioRxiv, 2021, 10.1101/2021.04.07.438684] PubMed: none

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。