Lycopene

製品コードS3943 バッチS394302

印刷

化学情報

Chemical Structure Synonyms ψ,ψ-Carotene Storage
(From the date of receipt)		 3 years -20°C(in the dark) powder
化学式

C40H56
分子量 536.87 CAS No. 502-65-8
Solubility (25°C)* 体外 0.1M NaOH 5 mg/mL warmed with 50ºC water bath (9.31 mM)
DMSO Insoluble
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant.
in vitro Lycopene is found in nature in the all-trans form; however, thermal processing, as well as intestinal digestion, of raw tomato products facilitates its cis-isomerization[3]. Lycopene is recognized to be the most efficient singlet oxygen quencher among biological carotenoids. Antioxidant functions are associated with lowering DNA damage, malignant transformation, and reducing biological oxidative damage of proteins, lipids, and other cell components in vitro. Lycopene has also been found to increase gap-junctional communication between cells and to induce the synthesis of connexin-43[1]. It negatively affects cancer cells or development of cancer by modulating cell cycle progression and cell proliferation and has an inhibitory effect on DNA synthesis, initiating up-regulation of gap-junction proteins and a reduction of local androgen signaling, impact IGIF-1 signaling, antioxidant activity and induction of apoptotic cell death[2].
in vivo Lycopene has been reported to increase the survival rate of mice exposed to X-ray radiation. Lycopene has been reported to increase the survival rate of mice exposed to X-ray radiation. It is found that the consumption of lycopene in fruits and vegetables may reduce the likelihood of developing heart disease. Lycopene prevents oxidation of low-density lipoprotein (LDL) cholesterol and reduces the risk of developing atherosclerosis and coronary heart disease. Lycopene is as effective as β-carotene in inhibiting the growth of the glioma cells in the model of glioma cells transplanted in rats[1]. Lycopene acts as an antioxidant agent both through a decrease in intracellular reactive species production in vitro and in vivo through the neutralization of reactive species, the restoration of the GSH/GSSG ratio, decrease in oxidatively generated damage and decrease in proinflammatory cytokines through decreased cell influx as well as direct suppression of cytokine production[3].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 HT-29, T84 and MCF-7 cells
濃度 1-5 μM
反応時間 48 and 96 h
実験の流れ

Human cell lines are treated with lycopene (1-5 μM) for 48 and 96 h. Cell viability is monitored using the method of MTT. The cell cycle is analyzed by flow cytometry, and apoptotic cells are identified by terminal deoxynucleotidyl transferase-mediated dUTP nick labeling (TUNEL) and by DAPI.
動物実験 動物モデル Male C57BL/6 mice
投薬量 25 or 50 mg/kg/day
投与方法 by orogastric gavage

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Enhancing regulatory T cell function via inhibition of high mobility group box 1 protein signaling in immune thrombocytopenia [ Haematologica, 2022, 10.3324/haematol.2022.281557] PubMed: 36263841

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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