MCC950 Sodium

製品コードS7809 バッチS780909

化学情報

	Synonyms	CP-456773 Sodium, CRID3 Sodium	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₀H₂₃N₂O₅S.Na
	分子量	426.46	CAS No.	256373-96-3
Solubility (25°C)*	体外	Water	85 mg/mL (199.31 mM)
		Ethanol	85 mg/mL (199.31 mM)
		DMSO	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
in vitro	MCC950 inhibits canonical and noncanonical NLRP3 activation in BMDM and HMDM cells at IC50 of 7.5 and 8.1nM. MCC950 specifically inhibits activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes.^[1]
in vivo	MCC950 reduces interleukin-1β (IL-1β) production and attenuates the severity of experimental autoimmune encephalomyelitis (EAE). Furthermore, MCC950 treatment rescues neonatal lethality in a mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome. ^[1]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	H9c2 cardiomyocyte cells
	濃度	7 nM
	反応時間	24 h
	実験の流れ	Cardiomyocytes were treated with NLRP3 inhibitor MCC950 for 24 h.
動物実験	動物モデル	C57BL/6 mice
	投薬量	50 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/25686105/
https://pubmed.ncbi.nlm.nih.gov/35013106/

カスタマーフィードバック

: Data from [Data independently produced by , , ARTHRITIS & RHEUMATOLOGY, 2017, 69(8):1636-1646]

: Data from [Data independently produced by , , Biochem Pharmacol, 2018, 154:278-292]

: Data from [Data independently produced by , , Biochem Biophys Res Commun, 2018, 503(4):3031-3037]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action [ J Exp Med, 2025, 222(11)e20242403]	PubMed: 40892070
LXR pathway drives hormonal response intensity in polycystic ovary syndrome [ EMBO Mol Med, 2025, 10.1038/s44321-025-00251-1]	PubMed: 40399491
Peroxiredoxin 1 promotes intestinal inflammation by activating the NLRP3 inflammasome in macrophages through lysosomal disruption in Crohn's disease [ Cell Death Dis, 2025, 16(1):565]	PubMed: 40715057
Co-exposure to polystyrene nanoplastics and glyphosate exacerbates NETs-mediated pyroptosis by activating the NLRP3 inflammasome in mouse liver [ Ecotoxicol Environ Saf, 2025, 302:118529]	PubMed: 40554107
PRRSV-2 nsp2 Ignites NLRP3 inflammasome through IKKβ-dependent dispersed trans-Golgi network translocation [ PLoS Pathog, 2025, 21(1):e1012915]	PubMed: 39869629
Effects of acute pro-inflammatory stimulation and 25-hydroxycholesterol on hippocampal plasticity and learning involve NLRP3 inflammasome and cellular stress responses [ Sci Rep, 2025, 15(1):6149]	PubMed: 39979396
Peroxiredoxin 1 inhibits tumorigenesis by activating the NLRP3/GSDMD pathway to induce pyroptosis of colorectal cancer cells [ World J Gastroenterol, 2025, 31(36):111557]	PubMed: 41025079
Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism [ Circ Res, 2024, 135(9):933-950]	PubMed: 39234670
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome [ Bone Res, 2024, 12(1):53]	PubMed: 39242551
Fenebrutinib, a Bruton's tyrosine kinase inhibitor, blocks distinct human microglial signaling pathways [ J Neuroinflammation, 2024, 21(1):276]	PubMed: 39465429

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。