受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | CP-456773 Sodium, CRID3 Sodium | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
|
化学式 | C20H23N2O5S.Na |
|||
分子量 | 426.46 | CAS No. | 256373-96-3 | |
Solubility (25°C)* | 体外 | Water | 85 mg/mL (199.31 mM) | |
Ethanol | 85 mg/mL (199.31 mM) | |||
DMSO | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes. |
---|---|
in vitro | MCC950 inhibits canonical and noncanonical NLRP3 activation in BMDM and HMDM cells at IC50 of 7.5 and 8.1nM. MCC950 specifically inhibits activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes.[1] |
in vivo | MCC950 reduces interleukin-1β (IL-1β) production and attenuates the severity of experimental autoimmune encephalomyelitis (EAE). Furthermore, MCC950 treatment rescues neonatal lethality in a mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome. [1] |
細胞アッセイ | 細胞株 | H9c2 cardiomyocyte cells |
---|---|---|
濃度 | 7 nM | |
反応時間 | 24 h | |
実験の流れ | Cardiomyocytes were treated with NLRP3 inhibitor MCC950 for 24 h. |
|
動物実験 | 動物モデル | C57BL/6 mice |
投薬量 | 50 mg/kg | |
投与方法 | i.p. |
|
Data from [Data independently produced by , , ARTHRITIS & RHEUMATOLOGY, 2017, 69(8):1636-1646]
Data from [Data independently produced by , , Biochem Pharmacol, 2018, 154:278-292]
Data from [Data independently produced by , , Biochem Biophys Res Commun, 2018, 503(4):3031-3037]
Tonic TCR and IL-1β signaling mediate phenotypic alterations of naive CD4+ T cells [ Cell Rep, 2024, 43(3):113954] | PubMed: 38492221 |
A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages [ Cell Rep, 2024, 43(4):113981] | PubMed: 38520688 |
sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK-JNK Signaling Pathway [ Biology (Basel), 2024, 13(2)87] | PubMed: 38392305 |
Force-induced Caspase-1-dependent pyroptosis regulates orthodontic tooth movement [ Int J Oral Sci, 2024, 16(1):3] | PubMed: 38221531 |
Clostridioides difficile aggravates dextran sulfate solution (DSS)-induced colitis by shaping the gut microbiota and promoting neutrophil recruitment [ Gut Microbes, 2023, 15(1):2192478] | PubMed: 36951545 |
Long-term exposure to house dust mites accelerates lung cancer development in mice [ J Exp Clin Cancer Res, 2023, 42(1):26] | PubMed: 36670473 |
The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice [ J Neuroinflammation, 2023, 20(1):112] | PubMed: 37165444 |
The microbiota regulates hematopoietic stem and progenitor cell development by mediating inflammatory signals in the niche [ Cell Rep, 2023, 42(2):112116] | PubMed: 36795566 |
Interrogating direct NLRP3 engagement and functional inflammasome inhibition using cellular assays [ Cell Chem Biol, 2023, S2451-9456(23)00335-5] | PubMed: 37858335 |
PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration [ Ecotoxicol Environ Saf, 2023, 252:114630] | PubMed: 36764072 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。