Menbutone

製品コードS4886 バッチS488601

印刷

化学情報

Synonyms

Genabilin, Naftobil, Genabilic acid

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₅H₁₄O₄

分子量

258.27

CAS No.

3562-99-0

Solubility (25°C)*

体外

DMSO

51 mg/mL (197.46 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Menbutone (Genabilin, Naftobil, Genabilic acid), or genabilic acid, is a derivative of oxybutyric acid which acts as a choleretic stimulating secretion, a trypsinogen and a pepsinogen.
in vivo	Acute toxicity of menbutone in rabbits occurrs at accidental high doses, as the lethal dose is about 50 fold over the recommended therapeutic dose for other animals. Cardiac muscle, liver and kidneys are the main target organs for menbutone toxicity. Menbutone is not recommended for use in rabbits suffering from any cardiac and hepatic disorders, especially in overdosing situations. The calculated LD50 is 475 mg/kg BW in rabbits, indicating that menbutone has a relatively wide safety margin^[1].

製品説明

Menbutone (Genabilin, Naftobil, Genabilic acid), or genabilic acid, is a derivative of oxybutyric acid which acts as a choleretic stimulating secretion, a trypsinogen and a pepsinogen.

in vivo

Acute toxicity of menbutone in rabbits occurrs at accidental high doses, as the lethal dose is about 50 fold over the recommended therapeutic dose for other animals. Cardiac muscle, liver and kidneys are the main target organs for menbutone toxicity. Menbutone is not recommended for use in rabbits suffering from any cardiac and hepatic disorders, especially in overdosing situations. The calculated LD50 is 475 mg/kg BW in rabbits, indicating that menbutone has a relatively wide safety margin^[1].

プロトコル(参考用のみ)

動物実験	動物モデル	healthy adult male rabbits
	投薬量	400, 450, 500, 550 and 600 mg/kg
	投与方法	intramuscular injection

参考

https://polipapers.upv.es/index.php/wrs/article/view/1791

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。