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Synonyms | Mercurochrome, Merbromine, Mercurocol, Sodium mercurescein, Asceptichrome, Supercrome, Brocasept, Cinfacromin | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C20H10Br2HgO6.2Na |
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分子量 | 752.68 | CAS No. | 129-16-8 | |
Solubility (25°C)* | 体外 | Water | 100 mg/mL (132.85 mM) | |
DMSO | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Merbromin (Mercurochrome), a xanthene dye and an antibacterial agent, is the first of a series of antiseptics that contained mercury, also is a mixed-type inhibitor of 3CLpro due to its ability of increasing the KM and decreasing the Kcat of 3CLpro. |
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in vitro | Merbromin strongly inhibites the proteolytic activity of 3CLpro which is a promising target for developing anti-SARS-CoV-2 drugs. Michaelis-Menten kinetic analysis shows that Merbromin is a mixed-type inhibitor of 3CLpro, indicating by its ability of increasing the KM and decreasing the Kcat of 3CLpro. And 3CLpro possessed two binding sites for Merbromin.[2] |
細胞アッセイ | 細胞株 | |
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濃度 | 0-30 μM | |
反応時間 | 3 min | |
実験の流れ | Enzyme concentration is initially designed to be 0.2 μM, and reaction is launched by rapidly adding substrate (final concentrations from 0 to 30 μM). After 3 min reaction, fluorometric hydrolysate is measured by Victor Nivo Microplate Reader. The enzyme activity of 3CLpro is represented by Michaelis constant K M and Conversion rate constant K cat, which are determined by nonlinear regression based on Michaelis-Menten equation. |
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長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。