受注:045-509-1970 |
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | ||||||||
化学式 | C21H19N3O4S2 |
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分子量 | 441.52 | CAS No. | 1532593-30-8 | ||||||||
Solubility (25°C)* | 体外 | DMSO | 88 mg/mL (199.31 mM) | ||||||||
Water | Insoluble | ||||||||||
Ethanol | Insoluble | ||||||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | ML355 is a potent and selective inhibitor of human 12-Lipoxygenase with an IC50 of 290 nM and shows excellent selectivity over related lipoxygenases and cyclooxygenases. |
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in vitro | ML355 displays nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases[1]. |
in vivo | In vivo PK studies where ML355 is administered as a solution via IV (3mpk) and PO (30mpk) demonstrated that ML355 is orally bioavailable (%F = 20) with good half-life (T1/2 = 2.9 hours). At 30 mpk dosing, ML355 achieves a Cmax of over 135 times the in vitro IC50 and remains over IC50 value for over 12 hours. The compound has low clearance (3.4 mL/min/kg) and good overall exposure (AUCinf) of 38 µM. Although, the volume of distribution (VD) observed is low (0.55 L/kg), the rest of the PK profiling results suggest a reasonable distribution between tissue and blood[1]. |
細胞アッセイ | 細胞株 | U87 cells |
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濃度 | 10 µM | |
反応時間 | 24 h | |
実験の流れ | Cells were treated with indicated concentration of drug for 24 h. |
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動物実験 | 動物モデル | C57BL/6 mice |
投薬量 | 15 or 30 mg/kg | |
投与方法 | p.o. |
Identification and Validation of a Novel Prognostic Signature Based on Ferroptosis-Related Genes in Ovarian Cancer [ Vaccines (Basel), 2023, 11(2)205] | PubMed: 36851083 |
Phospholipid peroxidation inhibits autophagy via stimulating the delipidation of oxidized LC3-PE [ Redox Biol, 2022, 55:102421] | PubMed: 35964342 |
miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities [ Oncogenesis, 2021, 10(2):15] | PubMed: 33579899 |
Lipid Receptor GPR31 (G-Protein-Coupled Receptor 31) Regulates Platelet Reactivity and Thrombosis Without Affecting Hemostasis [ Arterioscler Thromb Vasc Biol, 2020, ATVBAHA120315154] | PubMed: 33267659 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。