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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | ||||
化学式 | C29H25N3O4S |
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分子量 | 511.59 | CAS No. | 846557-71-9 | ||||
Solubility (25°C)* | 体外 | DMSO (warmed with 50ºC water bath) | 50 mg/mL (97.73 mM) | ||||
Water | Insoluble | ||||||
Ethanol | Insoluble | ||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins. |
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in vitro | ML385 shows anti-tumor activity in NSCLC (subcutaneous and orthotopic NSCLC models) both as a single agent and in combination with carboplatin. The PK profile tested in CD-1 mice shows that ML385 has a half-life (t1/2 = 2.82 h) after IP injection (30 mg/kg)[1]. ML385 could alleviate the pancreatic injury[2]. |
細胞アッセイ | 細胞株 | A549 cells |
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濃度 | 5 μM | |
反応時間 | 24, 48 and 72 h | |
実験の流れ | -- |
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動物実験 | 動物モデル | male CD-1 mice |
投薬量 | 30 mg/kg | |
投与方法 | i.p. |
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Inhibition of NRF2 enhances the acute myeloid leukemia cell death induced by venetoclax via the ferroptosis pathway [ Cell Death Discov, 2024, 10(1):35] | PubMed: 38238299 |
Hydrophobic Components in Light-Yellow Pulp Sweet Potato (Ipomoea batatas (L.) Lam.) Tubers Suppress LPS-Induced Inflammatory Responses in RAW264.7 Cells via Activation of the Nrf2 Pathway [ Nutrients, 2024, 16(4)563] | PubMed: 38398887 |
Cardioprotective effects of asiaticoside against diabetic cardiomyopathy: Activation of the AMPK/Nrf2 pathway [ J Cell Mol Med, 2024, 28(2):e18055] | PubMed: 38113341 |
Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2/HO-1 signaling pathway [ Eur J Pharmacol, 2024, 963:176264] | PubMed: 38123006 |
FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice [ Nat Commun, 2023, 14(1):6107] | PubMed: 37777507 |
FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice [ Nat Commun, 2023, 14(1):6107] | PubMed: 37777507 |
Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects [ Cell Rep Med, 2023, S2666-3791(23)00310-5] | PubMed: 37586364 |
Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects [ Cell Rep Med, 2023, 4(9):101157] | PubMed: 37586364 |
EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2 [ Redox Biol, 2023, 65:102825] | PubMed: 37531930 |
Targeting NRF2 uncovered an intrinsic susceptibility of acute myeloid leukemia cells to ferroptosis [ Exp Hematol Oncol, 2023, 12(1):47] | PubMed: 37198609 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。