ML385

製品コードS8790 バッチS879003

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₂₉H₂₅N₃O₄S

分子量

511.59

CAS No.

846557-71-9

Solubility (25°C)*

体外

DMSO (warmed with 50ºC water bath)

50 mg/mL (97.73 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	6%DMSO 1 40%PEG300 2 5%Tween80 3 49%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	1.500mg/ml (2.93mM)	Taking the 1 mL working solution as an example, add 60 μL 25 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 490 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins.
in vitro	ML385 shows anti-tumor activity in NSCLC (subcutaneous and orthotopic NSCLC models) both as a single agent and in combination. The PK profile tested in CD-1 mice shows that this compound has a half-life (t_1/2 = 2.82 h) after IP injection (30 mg/kg)^[1]. This chemical could alleviate the pancreatic injury^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	A549 cells
	濃度	5 μM
	反応時間	24, 48 and 72 h
	実験の流れ	--
動物実験	動物モデル	male CD-1 mice
	投薬量	30 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/27552339/
https://www.hindawi.com/journals/omcl/2018/7161592/
https://pubmed.ncbi.nlm.nih.gov/32907551/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Sodium nitrate protects against metabolic syndrome by sialin-mediated macrophage rebalance [ Signal Transduct Target Ther, 2025, 10(1):323]	PubMed: 41034188
Ferroptosis in acute liver Failure: Unraveling the hepcidin-ferroportin axis and therapeutic interventions [ Redox Biol, 2025, 84:103657]	PubMed: 40393152
5-HT regulates resistance to aumolertinib by attenuating ferroptosis in lung adenocarcinoma [ EMBO Mol Med, 2025, 10.1038/s44321-025-00293-5]	PubMed: 40897859
Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis [ J Neuroinflammation, 2025, 22(1):44]	PubMed: 39985040
Preventive hyperbaric oxygen therapy improves acute graft-versus-host disease by activating the Nrf2/HO-1 pathway [ Front Immunol, 2025, 16:1529176]	PubMed: 40083556
SAMSN1 causes sepsis immunosuppression by inducing macrophages to express coinhibitory molecules that cause T-cell exhaustion via KEAP1-NRF2 signaling [ Chin Med J (Engl), 2025, 138(13):1607-1620]	PubMed: 40293473
Oridonin mitigates bacterial pneumonia by regulating mitochondrial integrity and ferroptosis via targeting KEAP1/NRF2 signaling [ Biochem Pharmacol, 2025, 242(Pt 2):117310]	PubMed: 40925465
Hyperoxia-activated Nrf2 regulates ferroptosis in intestinal epithelial cells and intervenes in inflammatory reaction through COX-2/PGE2/EP2 pathway [ Mol Med, 2025, 31(1):1]	PubMed: 39754066
Ligustrazine hydrochloride Prevents Ferroptosis by Activating the NRF2 Signaling Pathway in a High-Altitude Cerebral Edema Rat Model [ Int J Mol Sci, 2025, 26(3)1110]	PubMed: 39940878
Transcriptional Repression of CCL2 by KCa3.1 K+ Channel Activation and LRRC8A Anion Channel Inhibition in THP-1-Differentiated M2 Macrophages [ Int J Mol Sci, 2025, 26(15)7624]	PubMed: 40806751

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。