Mogroside V

製品コードS3815 バッチS381501

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C60H102O29
分子量 1287.43 CAS No. 88901-36-4
Solubility (25°C)* 体外 DMSO 100 mg/mL (77.67 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit).
in vitro Mogroside V possesses tumor growth inhibitory activity in in vitro and in vivo models of pancreatic cancer by promoting apoptosis and cell cycle arrest of pancreatic cancer cells (PANC-1 cells), which may in part be mediated through regulating the STAT3 signaling pathway. Mogroside V inhibits the proliferation of pancreatic cancer cells and other tumor cell types in a dose- and time-dependent manner, and shows very little cytotoxicity against the non-tumorigenic epithelial cell line L02. Mogroside V inhibits the downstream targets of the STAT3 pathway that promote cell proliferation (CCND1, CCNE1 and CDK2), while also upregulating cell cycle inhibitors (CDKN1A and CDKN1B)[1].
in vivo Mogroside V treatment promotes apoptosis of pancreatic cancer cells in the xenograft tumors. Mogroside V treatment significantly reduces the expression of CD31-labeled blood vessels and of the pro-angiogenic factor vascular endothelial growth factor in the xenografts, indicating that mogroside V might limit the growth of pancreatic tumors by inhibiting angiogenesis and reducing vascular density. Mogroside V treatment inhibits tumor cell growth, induces apoptosis and causes tumor regression[1].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 PANC-1 cells
濃度 0 to 250 μmol/l
反応時間 24 or 72 h
実験の流れ Cells are added to 96-well cell culture plates at an initial concentration of 1 × 104 cells/ml and are incubated with the indicated concentrations of mogroside V. After 24 or 72 h of incubation, MTT solution (5 mg/ml) is added to the wells and the cells are incubated for another 4 h. The growth medium is removed and formazan crystals formed by oxidation of the MTT dye are analyzed by measuring the absorbance at 490 nm using an ELISA reader.
動物実験 動物モデル BALB/c nude mice xenografted with PANC-1 cells
投薬量 2 mg/kg, 10 mg/kg, 30 mg/kg
投与方法 i.v.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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