Acetylcysteine (N-Acetylcysteine, NAC)

製品コードS1623 バッチS162302

印刷

化学情報

Synonyms

N-acetylcysteine

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₅H₉NO₃S

分子量

163.19

CAS No.

616-91-1

Solubility (25°C)*

体外

DMSO

32 mg/mL (196.09 mM)

Water

32 mg/mL (196.09 mM)

Ethanol

32 mg/mL (196.09 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Acetylcysteine (N-acetyl-l-cysteine, NAC,N-acetylcysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions are unstable and should be fresh-prepared.
in vitro	Acetylcysteine (N-Acetylcysteine, NAC) inhibits activation of c-Jun N-terminal kinase, p38 MAP kinase and redox-sensitive activating protein-1 and nuclear factor kappa B transcription factor activities regulating expression of numerous genes. It can also prevent apoptosis and promote cell survival by activating extracellular signal-regulated kinase pathway, a concept useful for treating certain degenerative diseases. This compound directly modifies the activity of several proteins by its reducing activity. ^[1] It prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. It also prevents death of PC12 cells and sympathetic neurons. ^[2] It causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells. ^[3] It activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. It protects neuronal cells from death evoked by withdrawal of trophic support. It increases nitric oxide (NO) release from protein-bound stores in vascular tissue. Its pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it was suggested that NAC interferes with redox-sensitive steps in the NGF mechanism. ^[4]
in vivo	Acetylcysteine (N-Acetylcysteine, NAC) improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight. ^[5]

製品説明

Acetylcysteine (N-acetyl-l-cysteine, NAC,N-acetylcysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions are unstable and should be fresh-prepared.

in vitro

Acetylcysteine (N-Acetylcysteine, NAC) inhibits activation of c-Jun N-terminal kinase, p38 MAP kinase and redox-sensitive activating protein-1 and nuclear factor kappa B transcription factor activities regulating expression of numerous genes. It can also prevent apoptosis and promote cell survival by activating extracellular signal-regulated kinase pathway, a concept useful for treating certain degenerative diseases. This compound directly modifies the activity of several proteins by its reducing activity. ^[1]

It prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. It also prevents death of PC12 cells and sympathetic neurons. ^[2]

It causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells. ^[3]

It activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. It protects neuronal cells from death evoked by withdrawal of trophic support. It increases nitric oxide (NO) release from protein-bound stores in vascular tissue. Its pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it was suggested that NAC interferes with redox-sensitive steps in the NGF mechanism. ^[4]

in vivo

Acetylcysteine (N-Acetylcysteine, NAC) improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight. ^[5]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	MCF cells
	濃度	5 mM
	反応時間	24 h
	実験の流れ	Cells were treated with indicated concentration of Acetylcysteine (N-Acetylcysteine, NAC) for 24 h.
動物実験	動物モデル	Male SAMP8 mice
	投薬量	100 mg/kg
	投与方法	s.c.

参考

https://pubmed.ncbi.nlm.nih.gov/11897584/
https://pubmed.ncbi.nlm.nih.gov/7722634/
https://pubmed.ncbi.nlm.nih.gov/8631978/

https://pubmed.ncbi.nlm.nih.gov/9592085/
https://pubmed.ncbi.nlm.nih.gov/12603840/
https://pubmed.ncbi.nlm.nih.gov/23772801/
https://pubmed.ncbi.nlm.nih.gov/1544168/
https://pubmed.ncbi.nlm.nih.gov/29426002/
https://pubmed.ncbi.nlm.nih.gov/30294906/
https://pubmed.ncbi.nlm.nih.gov/35023619/

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カスタマーフィードバック

: Data from [Data independently produced by , , Biochem Pharmacol, 2017, 146:224-232]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

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PM2.5 exacerbates nasal epithelial barrier dysfunction in allergic rhinitis by inducing NLRP3-mediated pyroptosis via the AhR/CYP1A1/ROS axis [ J Hazard Mater, 2025, 492:138145]	PubMed: 40209413
NCOA4-dependent ferritinophagy drives perfluorooctanoic acid-triggered renal ferroptosis in chicken embryos [ J Hazard Mater, 2025, 499:140112]	PubMed: 41109030
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Multi-omics analysis of glycolytic reprogramming and ROS dynamics in host-specific responses to Salmonella Typhi infection in mice [ J Adv Res, 2025, S2090-1232(25)00345-5]	PubMed: 40393644
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The antitumor effects of lupenone on colon cancer and its mechanistic insights [ Phytomedicine, 2025, 145:156939]	PubMed: 40669211
Genetic disruption of the circadian gene Bmal1 in the intestinal epithelium reduces colonic inflammation [ EMBO Rep, 2025, 10.1038/s44319-025-00464-y]	PubMed: 40307620
The rheumatoid arthritis drug Auranofin targets peroxiredoxin 1 and peroxiredoxin 2 to trigger ROS-endoplasmic reticulum stress axis-mediated cell death and cytoprotective autophagy [ Free Radic Biol Med, 2025, 233:1-12]	PubMed: 40089079

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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