m6A (N6-methyladenosine)

製品コードS3190 バッチS319009

印刷

化学情報

Chemical Structure Synonyms NSC-29409, 6-Methyladenosine, N-Methyladenosine Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C11H15N5O4
分子量 281.27 CAS No. 1867-73-8
Solubility (25°C)* 体外 DMSO 56 mg/mL (199.09 mM)
Water 14 mg/mL (49.77 mM)
Ethanol 9 mg/mL (31.99 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 m6A (N6-methyladenosine) は、アデノシンのベース変更された類似体で、天然RNAの中のマイナーなヌクレオシドとして見つかります。
in vitro N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. It is also found in tRNA, rRNA, and small nuclear RNA(snRNA) as well as several long non-coding RNA, such as Xist. [1] [2] [3] N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA). [4] N6-Methyladenosine is a widespread RNA modification in many tissues with high levels in the brain. N6-Methyladenosine is enriched near stop codons and within 3’UTRs in both mouse and human mRNAs. [5] The recent discovery that FTO, an obesity risk gene, encodes an m6A demethylase implicates m6A as an important regulator of physiological processes. [6]
in vivo LD50: Mice >1g/kg (i.g.). [7]

プロトコル(参考用のみ)

カスタマーフィードバック

, , Biochem Biophys Res Commun, 2016, 476(4):340-5.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

A low-cost, low-input method establishment for m6A MeRIP-seq [ Biosci Rep, 2024, 44(1)BSR20231430] PubMed: 38113135
The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts [ Nucleic Acids Res, 2023, 51(2):517-535] PubMed: 35934316
METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS [ Oncol Rep, 2023, 49(5)94] PubMed: 36960869
Autophagy induction promoted by m6A reader YTHDF3 through translation upregulation of FOXO3 mRNA [ Nat Commun, 2022, 13(1):5845] PubMed: 36195598
The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts [ Nucleic Acids Res, 2022, gkac640] PubMed: 35934316
Alphaherpesvirus US3 protein-mediated inhibition of the m6A mRNA methyltransferase complex [ Cell Rep, 2022, 40(3):111107] PubMed: 35858564
The Alteration of m6A Modification at the Transcriptome-Wide Level in Human Villi During Spontaneous Abortion in the First Trimester [ Front Genet, 2022, 13:861853] PubMed: 35754822
Overexpression of m6A-factors METTL3, ALKBH5, and YTHDC1 alters HPV16 mRNA splicing [ Virus Genes, 2022, 58(2):98-112] PubMed: 35190939
NAR Breakthrough Article The S. cerevisiae m 6 A-reader Pho92 promotes timely [ HAL Open Science, 2022, 10.1093/nar/gkac640] PubMed: None
Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6-Methyladenosine-Modified RNAs [ ACS Pharmacol Transl Sci, 2022, 5(10):872-891] PubMed: 36268123

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。