Nab-Paclitaxel

製品コードE1068 バッチE106803

化学情報

	Synonyms		Storage (From the date of receipt)	Store at room temperature, 3 years.
	化学式	C47H51NO14
	分子量	853.91（Only for Paclitaxel）	CAS No.
Solubility (25°C)*	体外	Water	4 mg/mL
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Nab-Paclitaxel is a novel solvent-free paclitaxel in which the binding ratio of paclitaxel to human albumin is approximately 1:9. It is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimers and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared.
in vitro	Treating human pancreatic ductal adenocarcinoma cells first with gemcitabine followed by Nab-Paclitaxel at 48 hours is found to have the greatest inhibition of cell growth.^[3]
in vivo	In mice with human pancreatic cancer xenografts, nab-paclitaxel alone and in combination with gemcitabine deplete the desmoplastic stroma. The intratumoral concentration of gemcitabine is increased by 2.8-fold in mice receiving nab-paclitaxel plus gemcitabine versus those receiving gemcitabine alone.^[4]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Human pancreatic ductal adenocarcinoma cell lines
	濃度	100 nM
	反応時間	24 h
	実験の流れ	Cells are seeded in 96-well plates at a density of 1,000–5,000 cells per well in 100 μL medium. Nab-Paclitaxel and gemcitabine are added and incubated at 37°C for 24 hours. Proliferation Is measured by the alamarBlue assay.
動物実験	動物モデル	Mice harboring PANC265 xenograft(female athymic nude mice)
	投薬量	i.v.
	投与方法

参考

https://pubmed.ncbi.nlm.nih.gov/23770008/
https://pubmed.ncbi.nlm.nih.gov/24071503/
https://pubmed.ncbi.nlm.nih.gov/33087331/

https://pubmed.ncbi.nlm.nih.gov/21969517/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Inhibition of C5a-C5aR1 axis suppresses tumour progression by enhancing antitumour immunity and chemotherapeutic effect in pancreatic ductal adenocarcinoma [ Br J Cancer, 2025, 10.1038/s41416-025-03185-0]	PubMed: 41044172
Mechanism of enhancing chemotherapy efficacy in pancreatic ductal adenocarcinoma with paricalcitol and hydroxychloroquine [ Cell Rep Med, 2024, S2666-3791(24)00652-9]	PubMed: 39730001
Controlled Delivery of Paclitaxel via Stable Synthetic Protein Nanoparticles [ Adv Ther (Weinh), 2024, 7(11)2400208]	PubMed: 39575154
Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma [ J Transl Med, 2023, 21(1):730]	PubMed: 37848935

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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