Necrostatin 2 racemate (Nec-1s)

製品コードS8641 バッチS864102

化学情報

	Synonyms	7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₃H₁₂ClN₃O₂
	分子量	277.71	CAS No.	852391-15-2
Solubility (25°C)*	体外	DMSO	56 mg/mL (201.64 mM)
		Ethanol	56 mg/mL (201.64 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) は、Necrostatin-1 の安定型変異体です。これは、IDO を標的とする効果を持たない、より特異的な RIPK1 阻害剤であり、485 種類すべてのヒトキナーゼの中で、他のキナーゼよりも RIPK1 に対して 1000 倍以上選択的です。
in vitro	Necrostatin 2 racemate (Nec-1s) is a potent inhibitor of RIPK1 and cellular necroptosis while lacking IDO inhibitory activity.
in vivo	Necrostatin 2 racemate (Nec-1s) is effective in reducing brain injuries. It is a superior inhibitor suitable for use in vivo lacking a paradoxical sensitizing effect in TNF-induced lethality. This compound possesses several advantageous pharmacokinetic and pharmacodynamic characteristics in comparison to Nec-1. Its safety profile is also superior to that of Nec-1 for reduced in vivo and in vitro toxicity.

製品説明

Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) は、Necrostatin-1 の安定型変異体です。これは、IDO を標的とする効果を持たない、より特異的な RIPK1 阻害剤であり、485 種類すべてのヒトキナーゼの中で、他のキナーゼよりも RIPK1 に対して 1000 倍以上選択的です。

in vitro

Necrostatin 2 racemate (Nec-1s) is a potent inhibitor of RIPK1 and cellular necroptosis while lacking IDO inhibitory activity.

in vivo

Necrostatin 2 racemate (Nec-1s) is effective in reducing brain injuries. It is a superior inhibitor suitable for use in vivo lacking a paradoxical sensitizing effect in TNF-induced lethality.

This compound possesses several advantageous pharmacokinetic and pharmacodynamic characteristics in comparison to Nec-1. Its safety profile is also superior to that of Nec-1 for reduced in vivo and in vitro toxicity.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	BMDMs
	濃度	50 µM
	反応時間	6 h
	実験の流れ	Cells were treated with indicated concentrations of Necrostatin 2 racemate (Nec-1s).
動物実験	動物モデル	TNF-induced SIRS model (Female C57BL/6J WT mice)
	投薬量	0.6 mg/kg and 6 mg/kg
	投与方法	i.v.

参考

https://pubmed.ncbi.nlm.nih.gov/23190609/
https://pubmed.ncbi.nlm.nih.gov/30081531/
https://pubmed.ncbi.nlm.nih.gov/36198273/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

SIGLEC12 mediates plasma membrane rupture during necroptotic cell death [ Nature, 2025, 10.1038/s41586-025-09741-1]	PubMed: 41225007
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia [ Cell, 2025, S0092-8674(25)01233-4]	PubMed: 41265435
Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance [ Cancer Cell, 2025, S1535-6108(25)00132-1]	PubMed: 40215978
Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma [ Cancer Commun (Lond), 2025, 10.1002/cac2.70036]	PubMed: 40443016
MLKL‒OPTN axis regulates herpesvirus-induced neurological sequelae [ Clin Transl Med, 2025, 15(6):e70353]	PubMed: 40490945
Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL) [ Cell Death Discov, 2025, 11(1):495]	PubMed: 41173858
Reduction of intestinal RIPK1 ameliorates HFD-induced metabolic disorders in female mice [ iScience, 2025, 28(2):111906]	PubMed: 40028283
TRIM25 facilitates ferroptosis in ovarian cancer through promoting PIEZO1 K63-linked ubiquitination and degradation [ Transl Oncol, 2025, 56:102386]	PubMed: 40250035
7-Dehydrocholesterol dictates ferroptosis sensitivity [ Nature, 2024, 626(7998):411-418.]	PubMed: 38297130
The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation [ Immunity, 2024, S1074-7613(24)00221-8]	PubMed: 38744293

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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