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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C15H14O7 |
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分子量 | 306.27 | CAS No. | 970-74-1 | |
Solubility (25°C)* | 体外 | DMSO | 61 mg/mL (199.17 mM) | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | (-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions. |
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in vitro | (-)-Epigallocatechin (EGC) shows the anti-proliferation effects on AML cells. EGC-treated cells show not only the suppression of FLT3, but also the suppression of phosphorylation of MAPK, AKT and STAT5. EGC suppresses FLT3 expression through Hsp90[1]. EGC inhibits heregulin-β1 (HRG)-induced migration/invasion of MCF-7 human breast carcinoma cells. It does not cause modification of MCF-7 cell cycle phases. EGC inhibits HRG-induced phosphorylation of ErbB2/ErbB3 at a low cell confluence and does not activate Akt at either a low or high cell confluence[2]. |
細胞アッセイ | 細胞株 | MOLM-13, MOLM-14, MV4-11 and KOCL-48 cells |
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濃度 | 0-200 μM | |
反応時間 | 72 h | |
実験の流れ | Cell proliferation is determined by trypan blue dye exclusion test. Briefly, cells are seeded in 6-well plates at a density of 1×105 cells/ml in the presence of different concentrations of EGCG, EGC, ECG and C for 72 hours. After the treatment, 10 µl of the cell suspension is mixed with 10 µl of 0.4% trypan blue, and alive cells are counted manually using a hemacytometer. |
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FLI1 Regulates Histamine Decarboxylase Expression to Control Inflammation Signaling and Leukemia Progression [ J Inflamm Res, 2023, 16:2007-2020] | PubMed: 37193069 |
Aloperine inhibits hepatitis C virus entry into cells by disturbing internalisation from endocytosis to the membrane fusion process [ Eur J Pharmacol, 2020, 173323] | PubMed: 32622669 |
Green tea extract-biomembrane interaction study: The role of its two major components, (-)-epigallocatechin gallate and (-)-epigallocatechin [ Biochim Biophys Acta Biomembr, 2020, 1863(1):183476] | PubMed: 32946887 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。